Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms

Sricharan S. Veeturi; Hamidreza Rajabzadeh-Oghaz; Nándor K. Pintér; Muhammad Waqas; David M. Hasan; Kenneth V. Snyder; Adnan H. Siddiqui; Vincent M. Tutino

doi:10.1098/rsos.211119

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Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms

Journal article

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Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms

Sricharan S. Veeturi, Hamidreza Rajabzadeh-Oghaz, Nándor K. Pintér, Muhammad Waqas, David M. Hasan, Kenneth V. Snyder, Adnan H. Siddiqui and Vincent M. Tutino

Royal Society Open Science, Vol.8(11), pp.211119-211119

11/10/2021

DOI: 10.1098/rsos.211119

PMCID: PMC8580418

PMID: 34804573

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Abstract

Vessel wall enhancement (VWE) in contrast-enhanced magnetic resonance imaging (MRI) is a potential biomarker for intracranial aneurysm (IA) risk stratification. In this study, we investigated the relationship between VWE features, risk metrics, morphology and hemodynamics in 41 unruptured aneurysms. We reconstructed the IA geometries from MR angiography and mapped pituitary stalk-normalized MRI intensity on the aneurysm surface using an in-house tool. For each case, we calculated the maximum intensity (CRstalk) and IA risk (via size and the rupture resemblance score (RRS)). We performed correlation analysis to assess relationships between CRstalk and IA risk metrics (size and RRS), as well as each parameter encompassed in RRS, i.e. aneurysmal size ratio (SR), normalized wall shear stress (WSS) and oscillatory shear index. We found that CRstalk had a strong correlation (Pearson correlation coefficient, PCC = 0.630) with size and a moderate correlation (PCC = 0.472) with RRS, indicating an association between VWE and IA risk. Furthermore, CRstalk had a weak negative correlation with normalized WSS (PCC = −0.320) and a weak positive correlation with SR (PCC = 0.390). Local voxel-based analysis showed only a weak negative correlation between normalized WSS and contrast-enhanced MRI signal intensity (PCC = −0.240), suggesting that if low-normalized WSS induces enhancement-associated pathobiology, the effect is not localized.

Cerebral Aneurysm

Computational Fluid Dynamics

Hemodynamics

Magnetic Resonance Imaging

Physics And Biophysics

Vessel Wall Enhancement

Details

Title: Subtitle: Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
Creators: Sricharan S. Veeturi - University at Buffalo, State University of New York
Hamidreza Rajabzadeh-Oghaz - University at Buffalo, State University of New York
Nándor K. Pintér - Dent Neurologic Institute
Muhammad Waqas - University at Buffalo, State University of New York
David M. Hasan - University of Iowa
Kenneth V. Snyder - University at Buffalo, State University of New York
Adnan H. Siddiqui - University at Buffalo, State University of New York
Vincent M. Tutino
Resource Type: Journal article
Publication Details: Royal Society Open Science, Vol.8(11), pp.211119-211119
DOI: 10.1098/rsos.211119
PMID: 34804573
PMCID: PMC8580418
NLM abbreviation: R Soc Open Sci
ISSN: 2054-5703
eISSN: 2054-5703
Publisher: The Royal Society
Grant note: #RSG201049.2 / SUNY Research Seed Grant 1R43NS115314-01 / National Institutes of Health (http://dx.doi.org/10.13039/100000002) Brain Aneurysm Foundation (http://dx.doi.org/10.13039/100013490)
Alternative title: Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
Language: English
Date published: 11/10/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984419124302771

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