Aneurysm shape reconstruction from biplane angiograms in the ISUIA collection

Madhavan L Raghavan; Gaurav V Sharda; John Huston III; J Mocco; Ana W Capuano; James C Torner; Punam K Saha; Irene Meissner; Robert D Brown Jr; International Study of Unruptured Intracranial Aneurysms Investigators

doi:10.1007/s12975-014-0330-5

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Aneurysm shape reconstruction from biplane angiograms in the ISUIA collection

Journal article

Open access

Peer reviewed

Aneurysm shape reconstruction from biplane angiograms in the ISUIA collection

Madhavan L Raghavan, Gaurav V Sharda, John Huston III, J Mocco, Ana W Capuano, James C Torner, Punam K Saha, Irene Meissner, Robert D Brown Jr and International Study of Unruptured Intracranial Aneurysms Investigators

Translational stroke research, Vol.5(2), pp.252-259

04/2014

DOI: 10.1007/s12975-014-0330-5

PMCID: PMC4258537

PMID: 24477497

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Abstract

The International Study of Unruptured Intracranial Aneurysms (ISUIA) is an epidemiologic international study of the natural history of unruptured intracranial aneurysms that enrolled 4,060 subjects. A conventional biplane cerebral angiogram available for central review was required for enrollment resulting in a large database. Data on aneurysms that ruptured during follow-up of the 1,692 untreated subjects provides an opportunity to investigate the anatomic features that may be predictive of future rupture. The objective of the study is to develop and test a method for three-dimensional (3D) shape reconstruction of aneurysms using biplane angiographic data in the ISUIA for retrospective morphometric assessment. Beginning with the two boundaries of the biplane views, curve morphing techniques were employed to estimate a number of intermediate boundaries around the aneurysm sac resulting in the creation of a 3D sac surface. The method was tested using simulated biplane "angiograms" of pre-reconstructed 3D models of patient-specific aneurysms. An algorithm to perform the image analysis was developed, and the morphometric indices of 150 intracranial aneurysms in the ISUIA database were estimated. Simultaneously, experienced neuroradiologists made manual measurements of key dimensions in the sac from the biplane angiograms for all cases. 3D reconstructions using our proposed method matched well with the original pre-reconstructed 3D geometries and were consistent with manual measurements of the neuroradiologists for the ISUIA aneurysms. A method for reconstructing the 3D geometry of the intracranial aneurysm sac from biplane angiograms in the ISUIA database with reasonable fidelity has been developed.

Radiography

Models, Theoretical

Retrospective Studies

Intracranial Aneurysm - diagnostic imaging

Image Processing, Computer-Assisted

Humans

Details

Title: Subtitle: Aneurysm shape reconstruction from biplane angiograms in the ISUIA collection
Creators: Madhavan L Raghavan - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA, ml-raghavan@uiowa.edu
Gaurav V Sharda
John Huston III
J Mocco
Ana W Capuano
James C Torner
Punam K Saha
Irene Meissner
Robert D Brown Jr
International Study of Unruptured Intracranial Aneurysms Investigators
Resource Type: Journal article
Publication Details: Translational stroke research, Vol.5(2), pp.252-259
DOI: 10.1007/s12975-014-0330-5
PMID: 24477497
PMCID: PMC4258537
NLM abbreviation: Transl Stroke Res
ISSN: 1868-4483
eISSN: 1868-601X
Publisher: United States
Grant note: R01 HL083475 / NHLBI NIH HHS RC1 NS068092 / NINDS NIH HHS 5RC1 NS068092-02 / NINDS NIH HHS 5 R01 HL083475 / NHLBI NIH HHS
Language: English
Date published: 04/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995122702771

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