Journal article
Aneurysmal Subarachnoid Hemorrhage in Patients with Coronavirus Disease 2019 (COVID-19): A Case Series
World neurosurgery, Vol.153, pp.e259-e264
09/01/2021
DOI: 10.1016/j.wneu.2021.06.092
PMCID: PMC8260497
PMID: 34242830
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is a pressing public health issue. Although most cases do not result in severe illness requiring hospitalization, there is increasing evidence that SARS-CoV-2–induced inflammation can exacerbate pre-existing diseases. We sought to describe the characteristics of patients with aneurysmal subarachnoid hemorrhage who were actively or very recently infected with SARS-CoV-2.
We reviewed subarachnoid hemorrhage cases of patients who also were positive for SARS-CoV-2 at 5 high-volume cerebrovascular centers in the United States from March 2020 to January 2021. Cases of aneurysmal subarachnoid hemorrhage were analyzed.
A total of 10 patients were identified, consisting of 5 women (50%) and 5 men (50%). Median age was 38.5 years. Four of the 10 patients (40%) were asymptomatic with respect to SARS-CoV-2–related symptoms, 3 patients (30%) had mild-to-moderate symptoms, and 3 patients (30%) had severe coronavirus disease 2019 (COVID-19), with pneumonia and sepsis. Of the 10 cases, 4 had dissecting pseudoaneurysms (40%), 3 in the posterior circulation and 1 in the anterior circulation. Among 6 saccular/blister aneurysms, 4 (67%) were ≤4 mm in largest diameter.
Our experience with aneurysmal subarachnoid hemorrhage in patients positive for COVID-19 reveals a possibly distinct pattern compared with traditional aneurysmal subarachnoid hemorrhage, namely a high frequency of small aneurysms, dissecting pseudoaneurysms, and young patients.
Details
- Title: Subtitle
- Aneurysmal Subarachnoid Hemorrhage in Patients with Coronavirus Disease 2019 (COVID-19): A Case Series
- Creators
- William S. Dodd - Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USAPascal M. Jabbour - Thomas Jefferson UniversityAhmad Sweid - Thomas Jefferson UniversityStavropoula Tjoumakaris - Thomas Jefferson UniversityMichael R. Gooch - Thomas Jefferson UniversityFadi Al Saiegh - Thomas Jefferson UniversityDavid M. Hasan - University of IowaRobert M. Starke - University of MiamiPeter T. Kan - The University of Texas Medical Branch at GalvestonAdam J. Polifka - University of FloridaDimitri Laurent - University of FloridaKatharina M. Busl - University of FloridaRitam Ghosh - Thomas Jefferson UniversityBrian L. Hoh - University of FloridaNohra Chalouhi - University of Florida
- Resource Type
- Journal article
- Publication Details
- World neurosurgery, Vol.153, pp.e259-e264
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.wneu.2021.06.092
- PMID
- 34242830
- PMCID
- PMC8260497
- ISSN
- 1878-8750
- eISSN
- 1878-8769
- Language
- English
- Date published
- 09/01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984418913102771
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