Journal article
Aneusomies of chromosomes 8 and Y detected by fluorescence in situ hybridization are prognostic markers for pathological stage C (pT3N0M0) prostate carcinoma
Clinical cancer research, Vol.2(1), pp.137-145
1996
PMID: 9816100
Abstract
In an attempt to identify new prognostic markers, we performed fluorescence in situ hybridization (FISH) ploidy analysis of tumor tissue from patients with a targeted stage and histological grade of prostate carcinoma. We identified all 227 patients from the Mayo Clinic radical prostatectomy data base who had a high histological grade pathological stage C (pT3N0M0) tumor removed between 1966 and 1987. After histological review of the paraffin-embedded specimen blocks, 181 cases were suitable for FISH analysis using chromosome enumeration probes for chromosomes 7, 8, 10, 12, X, and Y. FISH detected 80 (44%) diploid, 22 (12%) tetraploid, and 79 (44%) aneuploid tumors. The common aneusomies were of chromosomes 7 and 8, which were present in 51 (28%) and 46 (25%) tumors, respectively. Aneusomies of chromosomes 10, 12, X, and Y were observed in 11 (6%), 15 (8%) 12 (7%) and 16 (9%) tumors, respectively. FISH aneuploid tumors showed a trend of more frequent systemic prostate cancer progression than nonaneuploid tumors (P = 0.060). For individual chromosome anomalies, gains of chromosome 8, aneusomy of chromosome 8, and aneusomy of chromosome Y correlated highly with systemic cancer progression (P = 0.006, 0.013, and 0.021, respectively). Gains of chromosome Y and aneusomy of chromosome Y were associated with an increased prostate cancer death rate (P < 0.001 for both). Multivariate analysis showed that gains of chromosome 8 and aneusomy of chromosome Y were significant independent "predictors" of systemic cancer progression (P = 0.008) and cancer death (P < 0.001), respectively. These results demonstrate that aneuploidy and specific aneusomies detected by FISH are potential markers for a poor prognosis in histological high-grade pathological stage C (pT3N0M0) prostate carcinoma.
Details
- Title: Subtitle
- Aneusomies of chromosomes 8 and Y detected by fluorescence in situ hybridization are prognostic markers for pathological stage C (pT3N0M0) prostate carcinoma
- Creators
- S Takahashi - Mayo clin. foundation, dep. urology, Rochester MN 55905, United StatesA Alcaraz - Mayo clin. foundation, dep. urology, Rochester MN 55905, United StatesJ. A Brown - Mayo clin. foundation, dep. urology, Rochester MN 55905, United StatesT. J Borell - Mayo clin. foundation, dep. urology, Rochester MN 55905, United StatesJ. F Herath - Mayo clin. foundation, dep. urology, Rochester MN 55905, United StatesE. J Bergstralh - Mayo clin. foundation, dep. urology, Rochester MN 55905, United StatesM. M Lieber - Mayo clin. foundation, dep. urology, Rochester MN 55905, United StatesR. B Jenkins - Mayo clin. foundation, dep. urology, Rochester MN 55905, United States
- Resource Type
- Journal article
- Publication Details
- Clinical cancer research, Vol.2(1), pp.137-145
- Publisher
- American Association for Cancer Research
- PMID
- 9816100
- ISSN
- 1078-0432
- eISSN
- 1557-3265
- Language
- English
- Date published
- 1996
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Urology
- Record Identifier
- 9984320064902771
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