Journal article
Angioinvasive fungal infections impacting the skin: Diagnosis, management, and complications
Journal of the American Academy of Dermatology, Vol.80(4), pp.883-898.e2
04/2019
DOI: 10.1016/j.jaad.2018.04.058
PMID: 30102950
Abstract
As discussed in the first article in this continuing medical education series, angioinvasive fungal infections pose a significant risk to immunocompromised and immunocompetent patients alike, with a potential for severe morbidity and high mortality. The first article in this series focused on the epidemiology and clinical presentation of these infections; this article discusses the diagnosis, management, and potential complications of these infections. The mainstay diagnostic tests (positive tissue culture with histologic confirmation) are often supplemented with serum biomarker assays and molecular testing (eg, quantitative polymerase chain reaction analysis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry) to ensure proper speciation. When an angioinvasive fungal infection is suspected or diagnosed, further workup for visceral involvement also is essential and may partially depend on the organism. Different fungal organisms have varied susceptibilities to antifungal agents, and knowledge on optimal treatment regimens is important to avoid the potential complications associated with undertreated or untreated fungal infections.
Details
- Title: Subtitle
- Angioinvasive fungal infections impacting the skin: Diagnosis, management, and complications
- Creators
- Anthony P Berger - Department of Dermatology, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, IowaBradley A Ford - Department of Pathology and Clinical Microbiology, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, IowaZoe Brown-Joel - University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, IowaBridget E Shields - Department of Dermatology, University of Wisconsin, Madison, WisconsinMisha Rosenbach - Department of Dermatology, University of Pennsylvania, Philadelphia, PennsylvaniaKarolyn A Wanat - Department of Dermatology and Pathology, University of Iowa, Iowa City, Iowa. Electronic address: kwanat@gmail.com
- Resource Type
- Journal article
- Publication Details
- Journal of the American Academy of Dermatology, Vol.80(4), pp.883-898.e2
- DOI
- 10.1016/j.jaad.2018.04.058
- PMID
- 30102950
- NLM abbreviation
- J Am Acad Dermatol
- ISSN
- 0190-9622
- eISSN
- 1097-6787
- Publisher
- Elsevier Inc; United States
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Dermatology; Pathology
- Record Identifier
- 9984046909102771
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