Journal article
Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum
Pathology, Vol.46(3), pp.199-204
04/2014
DOI: 10.1097/PAT.0000000000000073
PMID: 24614712
Abstract
Angiomatoid fibrous histiocytoma, a fibrohistiocytic tumour of intermediate malignancy that usually presents on extremities of young patients, has a broader clinical/histological spectrum than is widely appreciated. We summarise our experience with an emphasis on unusual features. Twenty-seven cases were analysed for clinical and histological features, including immunohistochemistry and FISH for rearrangements of EWSR1 or FUS. Five (19%) occurred in patients >40 years old, and ten (37%) occurred outside the extremities. Three that occurred in patients >40 years old arose in atypical locations. Evaluation for classical histological features (lym-phocytic cuff, fibrous pseudocapsule, pseudovascular spaces, haemorrhage, haemosiderin, and histiocytoid morphology) showed that all had two or more classical features. Unusual features were noted in many cases. Ten (37%) displayed significant areas of sclerosis; three of these ten had areas with a perineurioma-like pattern. Nine displayed at least moderate pleomorphism, with two exhibiting striking pleomorphism. Eight had eosinophils in the stroma, one with numerous eosinophils. One had a reticulated pattern of cells in a myxoid stroma. Mitotic rates were low [average 0.67/10 high power fields (HPFs)]. Three had atypical mitotic figures. Thirteen of 20 (65%) were CD68 positive, 11 of 17 (65%) were EMA positive, and 10 of 18 (56%) were desmin positive. Thirteen of 16 (81%) had a rearrangement of EWSR1; none had a FUS rearrangement. This series expands the spectrum of angiomatoid fibrous histiocytoma.
Details
- Title: Subtitle
- Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum
- Creators
- Summer L BohmanJohn R GoldblumBrian P RubinMunir R TanasSteven D Billings
- Resource Type
- Journal article
- Publication Details
- Pathology, Vol.46(3), pp.199-204
- Publisher
- Elsevier B.V
- DOI
- 10.1097/PAT.0000000000000073
- PMID
- 24614712
- ISSN
- 0031-3025
- eISSN
- 1465-3931
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Pathology
- Record Identifier
- 9984046825902771
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