Journal article
Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting
Molecular metabolism (Germany), Vol.6(8), pp.809-818
08/2017
DOI: 10.1016/j.molmet.2017.06.007
PMCID: PMC5518724
PMID: 28752045
Abstract
Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the kinetics of Angptl4 induction and tested the hypothesis that ANGPTL4 functions physiologically to reduce triglyceride delivery to adipose tissue during nutrient deprivation.
Gene expression, LPL activity, and triglyceride uptake were examined in fasted and fed wild-type and Angptl4−/− mice.
Angptl4 was strongly induced early in fasting, and this induction was suppressed in mice with access to food during the light cycle. Fasted Angptl4−/− mice manifested increased LPL activity and triglyceride uptake in adipose tissue compared to wild-type mice.
Angptl4 is induced early in fasting to divert uptake of fatty acids and triglycerides away from adipose tissues.
•Angptl4 is induced within the first few hours of fasting.•Angptl4 expression is driven by fasting rather than circadian rhythms.•Fasted Angptl4−/− mice have increased triglyceride uptake in adipose tissue.•Angptl4−/− mice also have increased LPL activity specifically in adipose tissue.•Data support a model where ANGPTL4 acts locally in adipose during fasting.
Details
- Title: Subtitle
- Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting
- Creators
- Emily M Cushing - Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United StatesXun Chi - Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United StatesKelli L Sylvers - Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United StatesShwetha K Shetty - Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United StatesMatthew J Potthoff - Department of Pharmacology and Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United StatesBrandon S.J Davies - Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Molecular metabolism (Germany), Vol.6(8), pp.809-818
- DOI
- 10.1016/j.molmet.2017.06.007
- PMID
- 28752045
- PMCID
- PMC5518724
- NLM abbreviation
- Mol Metab
- ISSN
- 2212-8778
- eISSN
- 2212-8778
- Publisher
- Elsevier GmbH
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01HL130146 [BSJD, R01DK106104 [MJP, T32GM082729 [EMC; DOI: 10.13039/100000968, name: American Heart Association Scientist Development, award: 12SDG8580004 [BSJD
- Language
- English
- Date published
- 08/2017
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984025275202771
Metrics
26 Record Views