Journal article
Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.273(4), pp.R1501-R1508
10/01/1997
DOI: 10.1152/ajpregu.1997.273.4.R1501
PMID: 9362317
Abstract
We examined the hypothesis that endogenous angiotensin II and angiotensin type 1 (AT1) receptors participate in the development of fetal right ventricular hypertrophy by studying the effects of AT1 receptor blockade on cardiac growth in fetal sheep subjected to constrictive banding of the pulmonary artery (PA). Seven pairs of twin fetuses were studied beginning at 126 ± 1 days gestation (term = 145 days). One twin was given losartan (10 mg ⋅ kg−1 ⋅ day−1iv) for 7 consecutive days after PA banding, and the other twin served as a saline-treated, PA-banded control. Four additional pairs of twins served as sham-operated controls. Fetal heart rate (HR) and mean arterial blood pressure (MABP) were similar in the two groups of PA-banded animals before treatment and remained unchanged in the PA-banded control group. Losartan resulted in a significant decrease ( P < 0.05) in MABP between days 0 and 7, whereas HR was not affected. Total body weight of the losartan-treated animals was significantly less ( P < 0.05) than twin PA-banded controls and nonbanded fetuses. Right ventricle weight-to-body weight ratios were similar in saline (2.29 ± 0.34 g/kg) and losartan-treated (2.11 ± 0.15 g/kg) PA-banded animals and significantly greater than that in nonbanded fetuses (1.52 ± 0.07 g/kg). Similar differences were seen in the right ventricle weight-to-left ventricle weight ratios. Right and left ventricle AT1 receptor mRNA and protein expression were also similar among the three groups, as were AT2 receptor mRNA levels. These data suggest that endogenous angiotensin II does not contribute to the development of pressure overload-induced right ventricular hypertrophy during fetal life and that expression of angiotensin receptors is not altered by increased afterload in the ovine fetus.
Details
- Title: Subtitle
- Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep
- Creators
- Jeffrey L Segar - Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242; andThomas D Scholz - Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242; andKurt A Bedell - Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242; andOliva M Smith - Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242; andDavid J Huss - Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53792Edward N Guillery - Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53792
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.273(4), pp.R1501-R1508
- DOI
- 10.1152/ajpregu.1997.273.4.R1501
- PMID
- 9362317
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 10/01/1997
- Academic Unit
- Microbiology and Immunology; Cardiology; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health
- Record Identifier
- 9984093454302771
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