Journal article
Angiotensin II-induced drinking and pressor responses to central or systemic irbesartan and losartan
Pharmacology, biochemistry and behavior, Vol.71(1-2), pp.139-146
2002
DOI: 10.1016/S0091-3057(01)00635-9
PMID: 11812516
Abstract
Angiotensin II (ANG II) is a peptide hormone that is important for maintaining blood pressure and body fluid homeostasis. Two nonpeptide angiotensin type 1 (AT1) receptor antagonists, irbesartan and losartan, were compared for their antidipsogenic and antihypertensive efficacy in both normotensive and hypertensive rats. ANG II-induced drinking and pressor responses were examined following central or systemic administration of irbesartan and losartan. Both agents inhibited the drinking response to ANG II in normotensive rats. Irbesartan was more effective than losartan at inhibiting pressor responses to ANG II in normotensive and hypertensive rats. These data indicate that centrally administered irbesartan may be somewhat more effective as an AT1 receptor antagonist than losartan. However, evaluating the antihypertensive efficacy of these drugs when administered systemically is complex due to several pharmacokinetic factors (e.g., metabolism and lipophilicity). © 2002 Elsevier Science Inc. All rights reserved.
Details
- Title: Subtitle
- Angiotensin II-induced drinking and pressor responses to central or systemic irbesartan and losartan
- Creators
- Angela J Grippo - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center. The University of Iowa, II Seashore Hall E., Iowa City, IA 52242-1407, United StatesRobert F Kirby - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center. The University of Iowa, II Seashore Hall E., Iowa City, IA 52242-1407, United StatesTerry G Beltz - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center. The University of Iowa, II Seashore Hall E., Iowa City, IA 52242-1407, United StatesAlan Kim Johnson - Departments of Psychology, Pharmacology, and Exercise Science, and the Cardiovascular Center. The University of Iowa, II Seashore Hall E., Iowa City, IA 52242-1407, United States
- Resource Type
- Journal article
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.71(1-2), pp.139-146
- Publisher
- Elsevier Science
- DOI
- 10.1016/S0091-3057(01)00635-9
- PMID
- 11812516
- ISSN
- 0091-3057
- eISSN
- 1873-5177
- Language
- English
- Date published
- 2002
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; University College Courses; Health and Human Physiology
- Record Identifier
- 9984213274302771
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