Journal article
Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer
Pancreas, Vol.48(6), pp.759-779
07/2019
DOI: 10.1097/MPA.0000000000001335
PMCID: PMC6581211
PMID: 31206467
Abstract
At the 2018 PancreasFest meeting, experts participating in basic research met to discuss the plethora of available animal models for studying exocrine pancreatic disease. In particular, the discussion focused on the challenges currently facing the field and potential solutions. That meeting culminated in this review, which describes the advantages and limitations of both common and infrequently used models of exocrine pancreatic disease, namely, pancreatitis and exocrine pancreatic cancer. The objective is to provide a comprehensive description of the available models but also to provide investigators with guidance in the application of these models to investigate both environmental and genetic contributions to exocrine pancreatic disease. The content covers both nongenic and genetically engineered models across multiple species (large and small). Recommendations for choosing the appropriate model as well as how to conduct and present results are provided.
Details
- Title: Subtitle
- Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer
- Creators
- Jami L SalomanKathryn M AlbersZobeida Cruz-Monserrate - The Ohio State University Wexner Medical CenterBrian M DavisMouad Edderkaoui - Cedars-Sinai Medical CenterGuido Eibl - University of California, Los AngelesAriel Y EpouheJeremy Y GedeonFred S GorelickPaul J Grippo - University of Illinois at ChicagoGuy E Groblewski - University of Wisconsin–MadisonSohail Z Husain - Stanford UniversityKeane K Y LaiStephen J Pandol - Cedars-Sinai Medical CenterAliye Uc - University of IowaLi Wen - Children's Hospital of PittsburghDavid C Whitcomb - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- Pancreas, Vol.48(6), pp.759-779
- DOI
- 10.1097/MPA.0000000000001335
- PMID
- 31206467
- PMCID
- PMC6581211
- NLM abbreviation
- Pancreas
- ISSN
- 0885-3177
- eISSN
- 1536-4828
- Grant note
- I01 BX004306 / BLRD VA K01 AA019996 / NIAAA NIH HHS U01 DK108306 / NIDDK NIH HHS R01 CA177857 / NCI NIH HHS K01 DK120737 / NIDDK NIH HHS R01 NS050758 / NINDS NIH HHS U01 DK108334 / NIDDK NIH HHS U01 DK108314 / NIDDK NIH HHS R01 DK118752 / NIDDK NIH HHS P01 DK098108 / NIDDK NIH HHS R01 CA223204 / NCI NIH HHS I01 BX003250 / BLRD VA R13 DK118902 / NIDDK NIH HHS P30 CA086862 / NCI NIH HHS K08 AA025112 / NIAAA NIH HHS T32 NS086749 / NINDS NIH HHS R01 NS031826 / NINDS NIH HHS P01 CA163200 / NCI NIH HHS R01 DK054021 / NIDDK NIH HHS P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 07/2019
- Academic Unit
- Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984312990602771
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