Journal article
Animal Models and Their Role in Understanding the Pathophysiology of Cystic Fibrosis-Associated Gastrointestinal Lesions
Annual review of pathology, Vol.16(1), pp.51-67
01/24/2021
DOI: 10.1146/annurev-pathol-022420-105133
PMID: 33497264
Abstract
The life expectancy of cystic fibrosis (CF) patients has greatly increased over the past decade, and researchers and clinicians must now navigate complex disease manifestations that were not a concern prior to the development of modern therapies. Explosive growth in the number of CF animal models has also occurred over this time span, clarifying CF disease pathophysiology and creating opportunities to understand more complex disease processes associated with an aging CF population. This review focuses on the CF-associated pathologies of the gastrointestinal system and how animal models have increased our understanding of this complex multisystemic disease. Although CF is primarily recognized as a pulmonary disease, gastrointestinal pathology occurs very commonly and can affect the quality of life for these patients. Furthermore, we discuss how next-generation genetic engineering of larger animal models will impact the field's understanding of CF disease pathophysiology and the development of novel therapeutic strategies.
Details
- Title: Subtitle
- Animal Models and Their Role in Understanding the Pathophysiology of Cystic Fibrosis-Associated Gastrointestinal Lesions
- Creators
- Katherine N Gibson-Corley - Roy J. and Lucille A. Carver College of MedicineJohn F Engelhardt - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Annual review of pathology, Vol.16(1), pp.51-67
- DOI
- 10.1146/annurev-pathol-022420-105133
- PMID
- 33497264
- ISSN
- 1553-4006
- eISSN
- 1553-4014
- Grant note
- R24 DK096518 / NIDDK NIH HHS P30 DK054759 / NIDDK NIH HHS RC2 DK124207 / NIDDK NIH HHS
- Language
- English
- Date published
- 01/24/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; The University of Iowa Institute for Vision Research; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984288562002771
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