Journal article
Animal Protein and the Risk of Kidney Stones: A Comparative Metabolic Study of Animal Protein Sources
The Journal of urology, Vol.192(1), pp.137-141
07/2014
DOI: 10.1016/j.juro.2014.01.093
PMID: 24518789
Abstract
We compared the effect of 3 animal protein sources on urinary stone risk.
A total of 15 healthy subjects completed a 3-phase randomized, crossover metabolic study. During each 1-week phase subjects consumed a standard metabolic diet containing beef, chicken or fish. Serum chemistry and 24-hour urine samples collected at the end of each phase were compared using mixed model repeated measures analysis.
Serum and urinary uric acid were increased for each phase. Beef was associated with lower serum uric acid than chicken or fish (6.5 vs 7.0 and 7.3 mg/dl, respectively, each p <0.05). Fish was associated with higher urinary uric acid than beef or chicken (741 vs 638 and 641 mg per day, p = 0.003 and 0.04, respectively). No significant difference among phases was noted in urinary pH, sulfate, calcium, citrate, oxalate or sodium. Mean saturation index for calcium oxalate was highest for beef (2.48), although the difference attained significance only compared to chicken (1.67, p = 0.02) but not to fish (1.79, p = 0.08).
Consuming animal protein is associated with increased serum and urine uric acid in healthy individuals. The higher purine content of fish compared to beef or chicken is reflected in higher 24-hour urinary uric acid. However, as reflected in the saturation index, the stone forming propensity is marginally higher for beef compared to fish or chicken. Stone formers should be advised to limit the intake of all animal proteins, including fish.
Details
- Title: Subtitle
- Animal Protein and the Risk of Kidney Stones: A Comparative Metabolic Study of Animal Protein Sources
- Creators
- Chad R Tracy - Department of Urology, University of Iowa, Iowa City, IowaSara Best - Department of Urology, University of Wisconsin-Madison, Madison, WisconsinAditya Bagrodia - Department of Urology, University of Texas Southwestern Medical Center, Dallas, TexasJohn R Poindexter - Jane and Charles Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TexasBeverly Adams-Huet - Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TexasKhashayar Sakhaee - Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TexasNaim Maalouf - Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TexasCharles Y.C Pak - Jane and Charles Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TexasMargaret S Pearle - Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.192(1), pp.137-141
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.juro.2014.01.093
- PMID
- 24518789
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Grant note
- UL1TR000451 / National Center for Advancing Translational Sciences, National Institutes of Health
- Language
- English
- Date published
- 07/2014
- Academic Unit
- Radiology; Urology
- Record Identifier
- 9984051591902771
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