Animal chamber for in vivo testing of toxic gases

P S Thorne; E N Lightfoot; J C Gonder; J A Will

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Journal article

Animal chamber for in vivo testing of toxic gases

P S Thorne, E N Lightfoot, J C Gonder and J A Will

Laboratory animal science (Chicago), Vol.33(5), pp.476-480

10/1983

PMID: 6645396

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Abstract

A closed-circuit chamber system for exposing animals to toxic concentrations of oxygen or nitrogen was designed and built. The facility was equipped with systems for the removal of carbon dioxide, ammonia, methane, water vapor, and particulates from the gas stream. Integral systems were built to monitor and control temperature (+/- 1 degree C), relative humidity (+/- 2%), oxygen concentration (10 to 100% +/- 0.5%), and methane concentration (below 2%). Operation was set at standard pressure (1.0 X 10(5) Newtons/m2). Hyperoxic studies have been performed on six species of rodents, as well as sheep, and have lasted from 1 to 28 days.

Rabbits

Cricetinae

Oxygen - toxicity

Animals

Guinea Pigs

Nitrogen - toxicity

Rats

Atmosphere Exposure Chambers

Sheep

Mice

Gases - toxicity

Details

Title: Subtitle: Animal chamber for in vivo testing of toxic gases
Creators: P S Thorne
E N Lightfoot
J C Gonder
J A Will
Resource Type: Journal article
Publication Details: Laboratory animal science (Chicago), Vol.33(5), pp.476-480
Publisher: United States
PMID: 6645396
ISSN: 0023-6764
Language: English
Date published: 10/1983
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health
Record Identifier: 9983997353602771

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