Journal article
Animal models for COVID-19
Nature (London), Vol.586(7830), pp.509-515
10/2020
DOI: 10.1038/s41586-020-2787-6
PMCID: PMC8136862
PMID: 32967005
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
Details
- Title: Subtitle
- Animal models for COVID-19
- Creators
- César Muñoz-Fontela - German Center for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, GermanyWen-Chun Liu - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAStanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USAWilliam E Dowling - Centre for Epidemic Preparedness Innovations (CEPI), Washington, DC, USASimon G P Funnell - National Infection Service, Public Health England, Salisbury, UKPierre-S Gsell - World Health Organization, Geneva, SwitzerlandA Ximena Riveros-Balta - World Health Organization, Geneva, SwitzerlandRandy A Albrecht - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAHanne Andersen - Bioqual Inc, Rockville, MD, USARalph S Baric - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAMiles W Carroll - National Infection Service, Public Health England, Salisbury, UKMarco Cavaleri - European Medicines Agency, Amsterdam, The NetherlandsChuan Qin - Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking, ChinaIan Crozier - Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USAKai Dallmeier - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, BelgiumLeon de Waal - Viroclinics Xplore, Schaijk, The NetherlandsEmmie de Wit - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USALeen Delang - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, BelgiumErik Dohm - Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, USAW Paul Duprex - Department of Microbiology and Molecular Genetics, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USADarryl Falzarano - VIDO-Intervac, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaCourtney L Finch - Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USAMatthew B Frieman - Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USABarney S Graham - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USALisa E Gralinski - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAKate Guilfoyle - Viroclinics Xplore, Schaijk, The NetherlandsBart L Haagmans - Department of Viroscience, Erasmus University Medical Center, Rotterdam, The NetherlandsGeraldine A Hamilton - Emulate Inc, Boston, MA, USAAmy L Hartman - Department of Microbiology and Molecular Genetics, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USASander Herfst - Department of Viroscience, Erasmus University Medical Center, Rotterdam, The NetherlandsSuzanne J F Kaptein - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, BelgiumWilliam B Klimstra - Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USAIvana Knezevic - World Health Organization, Geneva, SwitzerlandPhilip R Krause - Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, USAJens H Kuhn - Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USARoger Le Grand - Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Inserm, CEA, Université Paris-Saclay, Paris, FranceMark G Lewis - Bioqual Inc, Rockville, MD, USAPauline Maisonnasse - Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Inserm, CEA, Université Paris-Saclay, Paris, FranceAnita K McElroy - Division of Pediatric Infectious Diseases, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAVincent Munster - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USANadia Oreshkova - Wageningen Bioveterinary Research (WBVR), Wageningen University and Research, Lelystad, The NetherlandsAngela L Rasmussen - Center for Infection and Immunity, Columbia Mailman |School of Public Health, New York, NY, USAJoana Rocha-Pereira - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, BelgiumBarry Rockx - Department of Viroscience, Erasmus University Medical Center, Rotterdam, The NetherlandsEstefanía Rodríguez - German Center for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, GermanyThomas F Rogers - Division of Infectious Diseases, University of California San Diego, San Diego, CA, USAFrancisco J Salguero - National Infection Service, Public Health England, Salisbury, UKMichael Schotsaert - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAKoert J Stittelaar - Viroclinics Xplore, Schaijk, The NetherlandsHendrik Jan Thibaut - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, BelgiumChien-Te Tseng - Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USAJúlia Vergara-Alert - Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat Autònoma de Barcelona, Bellaterra, SpainMartin Beer - Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, GermanyTrevor Brasel - Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USAJasper F W Chan - Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaAdolfo García-Sastre - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAJohan Neyts - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, BelgiumDouglas S Reed - Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USAJuergen A Richt - College of Veterinary Medicine, Kansas State University, Manhattan, KS, USAChad J Roy - Tulane National Primate Research Center, Covington, LA, USAJoaquim Segalés - Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, Bellaterra, SpainSeshadri S Vasan - Department of Health Sciences, University of York, York, UKAna María Henao-Restrepo - World Health Organization, Geneva, Switzerland. henaorestrepoa@who.intDan H Barouch - Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu
- Resource Type
- Journal article
- Publication Details
- Nature (London), Vol.586(7830), pp.509-515
- Publisher
- England
- DOI
- 10.1038/s41586-020-2787-6
- PMID
- 32967005
- PMCID
- PMC8136862
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- Grant note
- R01 AI148166 / NIAID NIH HHS R01 AI129269 / NIAID NIH HHS P01 AI060699 / NIAID NIH HHS P51 OD011104 / NIH HHS 001 / World Health Organization
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984070974002771
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