Animal models for muscular dystrophy : valuable tools for the development of therapies

Valérie ALLAMAND; Kevin P CAMPBELL

doi:10.1093/hmg/9.16.2459

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Animal models for muscular dystrophy : valuable tools for the development of therapies

Journal article

Open access

Peer reviewed

Animal models for muscular dystrophy : valuable tools for the development of therapies

Valérie ALLAMAND and Kevin P CAMPBELL

Human molecular genetics, Vol.9(16), pp.2459-2467

2000

DOI: 10.1093/hmg/9.16.2459

PMID: 11005802

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Abstract

Since the identification of dystrophin as the causative factor in Duchenne muscular dystrophy, an increasing amount of information on the molecular basis of muscular dystrophies has facilitated the division of these heterogeneous disorders into distinct groups. As more light is being shed on the genes and proteins involved in muscular dystrophy, diagnosis of patients has improved enormously. In addition to naturally occurring animal models, a number of genetically engineered murine models for muscular dystrophy have been generated. These animal models have provided valuable clues to the understanding of the pathogenesis of these disorders. Furthermore, as therapeutic approaches are being developed, mutant animals represent good models in which they can be tested. The present review focuses on the recent advancements of gene transfer-based strategies, with a special emphasis on animal models for Duchenne and limb-girdle muscular dystrophies.

Biotechnology

Gene Therapy

Fundamental and applied biological sciences. Psychology

Classical genetics, quantitative genetics, hybrids

Vertebrata

Animals

Health. Pharmaceutical industry

Industrial applications and implications. Economical aspects

Biological and medical sciences

Genetics of eukaryotes. Biological and molecular evolution

Details

Title: Subtitle: Animal models for muscular dystrophy : valuable tools for the development of therapies
Creators: Valérie ALLAMAND - Howard Hughes Medical Institute, Department of Physiology and Biophysics and Department of Neurology, University of Iowa College of Medicine, 400 Eckstein Medical Research Building, Iowa City, IA 52242, United States
Kevin P CAMPBELL - Howard Hughes Medical Institute, Department of Physiology and Biophysics and Department of Neurology, University of Iowa College of Medicine, 400 Eckstein Medical Research Building, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Human molecular genetics, Vol.9(16), pp.2459-2467
DOI: 10.1093/hmg/9.16.2459
PMID: 11005802
NLM abbreviation: Hum Mol Genet
ISSN: 0964-6906
eISSN: 1460-2083
Publisher: Oxford University Press; Oxford
Language: English
Date published: 2000
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984020715402771

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