Animal models of exfoliation syndrome, now and future

Simon W M John; Jeffrey M Harder; John H Fingert; Michael G Anderson

doi:10.1097/IJG.0000000000000121

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Animal models of exfoliation syndrome, now and future

Journal article

Open access

Peer reviewed

Animal models of exfoliation syndrome, now and future

Simon W M John, Jeffrey M Harder, John H Fingert and Michael G Anderson

Journal of glaucoma, Vol.23(8 Suppl 1), pp.S68-S72

10/2014

DOI: 10.1097/IJG.0000000000000121

PMCID: PMC4383291

PMID: 25275912

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Abstract

At present, no animal models fully embody exfoliation syndrome or exfoliation glaucoma. Both genetic and environmental factors appear critical for disease manifestation, and both must be considered when generating animal models. Because mice provide a powerful mammalian platform for modeling complex disease, this paper focuses on mouse models of exfoliation syndrome and exfoliation glaucoma.

Animals

Glaucoma, Open-Angle - genetics

Humans

Exfoliation Syndrome - complications

Mice, Transgenic

Mice

Glaucoma, Open-Angle - complications

Exfoliation Syndrome - genetics

Disease Models, Animal

Mice, Knockout

Details

Title: Subtitle: Animal models of exfoliation syndrome, now and future
Creators: Simon W M John - Howard Hughes Medical Institute
Jeffrey M Harder
John H Fingert
Michael G Anderson
Resource Type: Journal article
Publication Details: Journal of glaucoma, Vol.23(8 Suppl 1), pp.S68-S72
DOI: 10.1097/IJG.0000000000000121
PMID: 25275912
PMCID: PMC4383291
NLM abbreviation: J Glaucoma
ISSN: 1536-481X
eISSN: 1536-481X
Publisher: United States
Grant note: R01 EY011721 / NEI NIH HHS Howard Hughes Medical Institute R01 EY017673 / NEI NIH HHS
Language: English
Date published: 10/2014
Academic Unit: Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences
Record Identifier: 9983980089902771

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