Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology

Alicia K Olivier; Katherine N Gibson-Corley; David K Meyerholz

doi:10.1152/ajpgi.00146.2014

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Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology

Journal article

Open access

Peer reviewed

Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology

Alicia K Olivier, Katherine N Gibson-Corley and David K Meyerholz

American journal of physiology: Gastrointestinal and liver physiology, Vol.308(6), pp.G459-G471

03/15/2015

DOI: 10.1152/ajpgi.00146.2014

PMCID: PMC4360044

PMID: 25591863

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Abstract

Multiple organ systems, including the gastrointestinal tract, pancreas, and hepatobiliary systems, are affected by cystic fibrosis (CF). Many of these changes begin early in life and are difficult to study in young CF patients. Recent development of novel CF animal models has expanded opportunities in the field to better understand CF pathogenesis and evaluate traditional and innovative therapeutics. In this review, we discuss manifestations of CF disease in gastrointestinal, pancreatic, and hepatobiliary systems of humans and animal models. We also compare the similarities and limitations of animal models and discuss future directions for modeling CF.

Gastrointestinal Diseases - physiopathology

Species Specificity

Cystic Fibrosis - physiopathology

Humans

Gastrointestinal Diseases - etiology

Liver Diseases - etiology

Biliary Tract Diseases - physiopathology

Pancreatic Diseases - etiology

Pancreatic Diseases - physiopathology

Disease Models, Animal

Mice, Inbred CFTR

Genetic Predisposition to Disease

Pancreatic Diseases - metabolism

Cystic Fibrosis - metabolism

Cystic Fibrosis Transmembrane Conductance Regulator - metabolism

Cystic Fibrosis - complications

Phenotype

Animals

Gastrointestinal Diseases - metabolism

Cystic Fibrosis - genetics

Biliary Tract Diseases - etiology

Cystic Fibrosis Transmembrane Conductance Regulator - genetics

Liver Diseases - physiopathology

Mutation

Liver Diseases - metabolism

Biliary Tract Diseases - metabolism

Details

Title: Subtitle: Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology
Creators: Alicia K Olivier - Department of Pathology and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
Katherine N Gibson-Corley - Department of Pathology and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa
David K Meyerholz - Department of Pathology and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa david-meyerholz@uiowa.edu
Resource Type: Journal article
Publication Details: American journal of physiology: Gastrointestinal and liver physiology, Vol.308(6), pp.G459-G471
DOI: 10.1152/ajpgi.00146.2014
PMID: 25591863
PMCID: PMC4360044
NLM abbreviation: Am J Physiol Gastrointest Liver Physiol
ISSN: 0193-1857
eISSN: 1522-1547
Grant note: R24 DK-096518 / NIDDK NIH HHS HL-51670 / NHLBI NIH HHS P01 HL091842 / NHLBI NIH HHS P30 DK-54759 / NIDDK NIH HHS R24 DK096518 / NIDDK NIH HHS HL-091842 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS
Language: English
Date published: 03/15/2015
Academic Unit: Pathology; Ophthalmology and Visual Sciences
Record Identifier: 9984083890902771

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