Journal article
Animal models of soft-tissue sarcoma
Disease models & mechanisms, Vol.3(9-10), pp.557-566
09/2010
DOI: 10.1242/dmm.005223
PMCID: PMC2931534
PMID: 20713645
Abstract
Soft-tissue sarcomas (STSs) are rare mesenchymal tumors that arise from muscle, fat and connective tissue. Currently, over 75 subtypes of STS are recognized. The rarity and heterogeneity of patient samples complicate clinical investigations into sarcoma biology. Model organisms might provide traction to our understanding and treatment of the disease. Over the past 10 years, many successful animal models of STS have been developed, primarily genetically engineered mice and zebrafish. These models are useful for studying the relevant oncogenes, signaling pathways and other cell changes involved in generating STSs. Recently, these model systems have become preclinical platforms in which to evaluate new drugs and treatment regimens. Thus, animal models are useful surrogates for understanding STS disease susceptibility and pathogenesis as well as for testing potential therapeutic strategies.
Details
- Title: Subtitle
- Animal models of soft-tissue sarcoma
- Creators
- Rebecca D Dodd - LSRC Building, Duke University, NC 27708, USAJeffery K MitoDavid G Kirsch
- Resource Type
- Journal article
- Publication Details
- Disease models & mechanisms, Vol.3(9-10), pp.557-566
- DOI
- 10.1242/dmm.005223
- PMID
- 20713645
- PMCID
- PMC2931534
- NLM abbreviation
- Dis Model Mech
- ISSN
- 1754-8403
- eISSN
- 1754-8411
- Grant note
- R01 CA 138265 / NCI NIH HHS T32 GM007171 / NIGMS NIH HHS T32-GM-07171 / NIGMS NIH HHS R01 CA138265 / NCI NIH HHS
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094394402771
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