Journal article
Ankle osteoarthritis: Toward new understanding and opportunities for prevention and intervention
Journal of orthopaedic research, Vol.42(12), pp.2613-2622
12/2024
DOI: 10.1002/jor.25973
PMCID: PMC11981820
PMID: 39269016
Appears in UI Libraries Support Open Access
Abstract
Abstract The ankle infrequently develops primary osteoarthritis (OA), especially when compared to the hip and the knee. Ankle OA instead generally develops only after trauma. The consequences of end‐stage ankle OA can nonetheless be extremely debilitating, with impairment comparable to that of end‐stage kidney disease or congestive heart failure. Disconcertingly, evidence suggests that ankle OA can develop more often than is generally appreciated after even low‐energy rotational ankle fractures and chronic instability associated with recurrent ankle sprains, albeit at a slower rate than after more severe trauma. The mechanisms whereby ankle OA develops after trauma are poorly understood, but mechanical factors are implicated. A better understanding of the prevalence and mechanical etiology of post‐traumatic ankle OA can lead to better prevention and mitigation. New surgical and conservative interventions, including improved ligamentous repair strategies and custom carbon fiber bracing, hold promise for advancing treatment that may prevent residual ankle instability and the development of ankle OA. Studies are needed to fill in key knowledge gaps here related to etiology so that the interventions can target key factors. New technologies, including weight bearing CT and biplane fluoroscopy, offer fresh opportunities to better understand the relationships between trauma, ankle alignment, residual ankle instability, OA development, and foot/ankle function. This paper begins by reviewing the epidemiology of post‐traumatic ankle OA, presents evidence suggesting that new treatment options might be successful at preventing ankle OA, and then highlights recent technical advances in understanding of the origins of ankle OA to identify directions for future research.
Details
- Title: Subtitle
- Ankle osteoarthritis: Toward new understanding and opportunities for prevention and intervention
- Creators
- Donald D. Anderson - University of IowaJason Wilken - University of IowaWilliam Ledoux - VA Puget Sound Health Care SystemAmy L. Lenz - University of UtahMark E. Easley - Duke Medical CenterCesar de Cesar Netto - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic research, Vol.42(12), pp.2613-2622
- DOI
- 10.1002/jor.25973
- PMID
- 39269016
- PMCID
- PMC11981820
- NLM abbreviation
- J Orthop Res
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- Publisher
- Wiley
- Grant note
- Congressionally Directed Medical Research Programs: W81XWH-18-1-0658 National Institute of Arthritis and Musculoskeletal and Skin Diseases: K01AR080221 U.S. Department of Veterans Affairs: RX002970
Congressionally Directed Medical Research Programs, Grant/Award Number: W81XWH-18-1-0658; National Institute of Arthritis and Musculoskeletal and Skin Diseases, Grant/Award Number: K01AR080221; Arthritis Foundation; Orthopaedic Research and Education Foundation; Orthopaedic Trauma Association; U.S. Department of Veterans Affairs, Grant/Award Number: RX002970
- Language
- English
- Electronic publication date
- 09/13/2024
- Date published
- 12/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Industrial and Systems Engineering; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984704840302771
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