Journal article
Annual Research Review: The promise of stem cell research for neuropsychiatric disorders
Journal of child psychology and psychiatry, Vol.52(4), pp.504-516
04/2011
DOI: 10.1111/j.1469-7610.2010.02348.x
PMCID: PMC3124336
PMID: 21204834
Abstract
The study of the developing brain has begun to shed light on the underpinnings of both early and adult onset neuropsychiatric disorders. Neuroimaging of the human brain across developmental time points and the use of model animal systems have combined to reveal brain systems and gene products that may play a role in autism spectrum disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder and many other neurodevelopmental conditions. However, precisely how genes may function in human brain development and how they interact with each other leading to psychiatric disorders is unknown. Because of an increasing understanding of neural stem cells and how the nervous system subsequently develops from these cells, we have now the ability to study disorders of the nervous system in a new way - by rewinding and reviewing the development of human neural cells. Induced pluripotent stem cells (iPSCs), developed from mature somatic cells, have allowed the development of specific cells in patients to be observed in real time. Moreover, they have allowed some neuronal-specific abnormalities to be corrected with pharmacological intervention in tissue culture. These exciting advances based on the use of iPSCs hold great promise for understanding, diagnosing and, possibly, treating psychiatric disorders. Specifically, examination of iPSCs from typically developing individuals will reveal how basic cellular processes and genetic differences contribute to individually unique nervous systems. Moreover, by comparing iPSCs from typically developing individuals and patients, differences at stem cell stages, through neural differentiation, and into the development of functional neurons may be identified that will reveal opportunities for intervention. The application of such techniques to early onset neuropsychiatric disorders is still on the horizon but has become a reality of current research efforts as a consequence of the revelations of many years of basic developmental neurobiological science.
Details
- Title: Subtitle
- Annual Research Review: The promise of stem cell research for neuropsychiatric disorders
- Creators
- Flora M Vaccarino - Child Study Center, Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA. flora.vaccarino@yale.eduAlexander Eckehart UrbanHanna E StevensAnna SzekelyAlexej AbyzovElena L GrigorenkoMark GersteinSherman Weissman
- Resource Type
- Journal article
- Publication Details
- Journal of child psychology and psychiatry, Vol.52(4), pp.504-516
- DOI
- 10.1111/j.1469-7610.2010.02348.x
- PMID
- 21204834
- PMCID
- PMC3124336
- NLM abbreviation
- J Child Psychol Psychiatry
- ISSN
- 0021-9630
- eISSN
- 1469-7610
- Publisher
- England
- Grant note
- R21 MH087879-02 / NIMH NIH HHS R25 MH077823 / NIMH NIH HHS R01 MH089176-02 / NIMH NIH HHS R01 MH089176 / NIMH NIH HHS R21 MH087879 / NIMH NIH HHS R01 MH067715 / NIMH NIH HHS
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984070580302771
Metrics
29 Record Views