Journal article
Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment
Journal of bone metabolism, Vol.26(3), pp.133-143
08/01/2019
DOI: 10.11005/jbm.2019.26.3.133
PMCID: PMC6746661
PMID: 31555610
Abstract
Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to disease management. Available research suggests that low body weight and decreased gonadal function are the strongest predictors of bone loss and fractures in patients with AN. Additionally, other metabolic disturbances have been linked to bone loss, including growth hormone resistance, low leptin concentrations, and hypercortisolemia, but those correlations are less consistent and lack evidence of causality. In terms of treatment of AN-related bone disease, weight gain has the most robust impact on bone mineral density (BMD). Restoration of gonadal function seems to augment this effect and may independently improve BMD. Bisphosphonates, insulin-like growth factor 1 supplementation, and teriparatide may also be reasonable considerations, however need long-term efficacy and safety data.
Details
- Title: Subtitle
- Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment
- Creators
- Jeremy Steinman - Roy J. and Lucille A. Carver College of MedicineAmal Shibli-Rahhal - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of bone metabolism, Vol.26(3), pp.133-143
- Publisher
- The Korean Society for Bone and Mineral Research
- DOI
- 10.11005/jbm.2019.26.3.133
- PMID
- 31555610
- PMCID
- PMC6746661
- ISSN
- 2287-6375
- eISSN
- 2287-7029
- Language
- English
- Date published
- 08/01/2019
- Academic Unit
- Medicine Administration; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359593802771
Metrics
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