Journal article
Anorexia Nervosa and Osteoporosis
Calcified tissue international, Vol.110(5), pp.562-575
05/2022
DOI: 10.1007/s00223-021-00826-3
PMID: 33666707
Abstract
Patients with anorexia nervosa (AN) often experience low bone mineral density (BMD) and increased fracture risk, with low body weight and decreased gonadal function being the strongest predictors of the observed bone mineral deficit and fractures. Other metabolic disturbances have also been linked to bone loss in this group of patients, including growth hormone resistance, low insulin-like growth factor-1 (IGF-1) concentrations, low leptin concentrations, and hypercortisolemia. However, these correlations lack definitive evidence of causality. Weight restoration and resumption of menstrual function have the strongest impact on increasing BMD. Other potential treatment options include bisphosphonates and teriparatide, supported by data from small clinical trials, but these agents are not approved for the treatment of low BMD in adolescents or premenopausal women with AN.
Details
- Title: Subtitle
- Anorexia Nervosa and Osteoporosis
- Creators
- Chermaine Hung - University of IowaMarcus Muñoz - Roy J. and Lucille A. Carver College of MedicineAmal Shibli-Rahhal - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Calcified tissue international, Vol.110(5), pp.562-575
- DOI
- 10.1007/s00223-021-00826-3
- PMID
- 33666707
- ISSN
- 0171-967X
- eISSN
- 1432-0827
- Language
- English
- Date published
- 05/2022
- Academic Unit
- Medicine Administration; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359893802771
Metrics
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