Journal article
Antenatal Vitamin A Supplementation Increases Birth Weight and Decreases Anemia among Infants Born to Human Immunodeficiency Virus-Infected Women in Malawi
Clinical infectious diseases, Vol.35(5), pp.618-624
09/01/2002
DOI: 10.1086/342297
PMID: 12173139
Abstract
Vitamin A is essential for immunity and growth. A controlled clinical that involved 697 human immunodeficiency virus (HIV)-infected pregnant women was conducted to determine whether vitamin A prevents anemia, low birth weight, growth failure, HIV transmission, and mortality. Women received daily doses of iron and folate, either alone or combined with vitamin A (3 mg retinol equivalent), from 18–28 weeks' gestation until delivery. In the vitamin A and control groups, respectively, the mean (±SE) birth weights were 2895 ± 31 g and 2805 ± 32 g (P = .05), the proportions of low-birth-weight infants were 14.0% and 21.1% (P = .03), the proportions of anemic infants at 6 weeks postpartum were 23.4% and 40.6% (P < .001), and the respective cumulative proportions of infants who were HIV infected at 6 weeks and 24 months of age were 26.6% and 27.8% (P = .76) and 27.7% and 32.8% (P = .21). Receipt of vitamin A improved birth weight and neonatal growth and reduced anemia, but it did not affect perinatal HIV transmission.
Details
- Title: Subtitle
- Antenatal Vitamin A Supplementation Increases Birth Weight and Decreases Anemia among Infants Born to Human Immunodeficiency Virus-Infected Women in Malawi
- Creators
- Newton Kumwenda - Department of Epidemiology and Ophthalmology, Johns Hopkins University School of Hygiene and Public Health and School of MedicinePaolo G Miotti - National Institute of Allergy and Infectious DiseasesTaha E Taha - Department of Epidemiology and Ophthalmology, Johns Hopkins University School of Hygiene and Public Health and School of MedicineRobin Broadhead - Department of Paediatrics and Child Health, College of Medicine, University of MalawiRobert J Biggar - National Cancer InstituteJ. Brooks Jackson - Department of Pathology, Johns Hopkins University School of Hygiene and Public Health and School of MedicineGeorge Melikian - Department of Epidemiology and Ophthalmology, Johns Hopkins University School of Hygiene and Public Health and School of MedicineRichard D Semba - Department of Epidemiology and Ophthalmology, Johns Hopkins University School of Hygiene and Public Health and School of Medicine
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.35(5), pp.618-624
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/342297
- PMID
- 12173139
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 09/01/2002
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047767702771
Metrics
27 Record Views