Journal article
Antenatal factors modulate hearing screen failure risk in preterm infants
Archives of disease in childhood. Fetal and neonatal edition, Vol.101(1), pp.56-F61
01/2016
DOI: 10.1136/archdischild-2014-307843
PMID: 26195624
Abstract
ObjectiveThe objective of this study was to characterise the effects of antenatal inflammatory factors and maternal therapies on neonatal hearing screen outcomes in very low birthweight infants.MethodsWe conducted a retrospective study of a cohort of infants <33 weeks’ gestational age and <1501 g birth weight prospectively enrolled between 1999 and 2003 for whom placental pathology, cord blood interleukin (IL) 6, IL-1ß, tumour necrosis factor-α and neonatal hearing screen results were available.ResultsOf 289 infants with documented hearing screen results, 244 (84%) passed and 45 (16%) failed the hearing screen (unilateral, N=25 (56%); bilateral, N=20 (44%)). In the final logistic model, the fetal inflammatory response syndrome defined as the presence of fetal vasculitis and/or cord serum IL-6>18.2 pg/mL was the factor with greatest risk for hearing screen failure (OR 3.62, 95% CI 1.38 to 9.5). A patent ductus arteriosus treated with indomethacin significantly increased the risk (OR 3.3, 95% CI 1.3 to 8.26), while combined maternal steroid and magnesium sulfate exposure (0.37, 95% CI 0.11 to 0.81) reduced the risk for hearing screen failure.ConclusionsIntrauterine infection with a fetal inflammatory response is a risk factor for neonatal hearing loss while maternal therapies significantly reduced the risk of neonatal hearing loss in very low birthweight infants.
Details
- Title: Subtitle
- Antenatal factors modulate hearing screen failure risk in preterm infants
- Creators
- Jocelyn C Leung - Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USAChristina L Cifra - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USAAlexander G Agthe - Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USAChen-Chih J Sun - Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USARose M Viscardi - Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
- Resource Type
- Journal article
- Publication Details
- Archives of disease in childhood. Fetal and neonatal edition, Vol.101(1), pp.56-F61
- DOI
- 10.1136/archdischild-2014-307843
- PMID
- 26195624
- ISSN
- 1359-2998
- eISSN
- 1468-2052
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984093458802771
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