Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory

Jangjin Kim; Edward A Wasserman; Leyre Castro; John H Freeman

doi:10.1037/bne0000117

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Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory

Journal article

Open access

Peer reviewed

Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory

Jangjin Kim, Edward A Wasserman, Leyre Castro and John H Freeman

Behavioral neuroscience, Vol.130(1), pp.75-90

02/2016

DOI: 10.1037/bne0000117

PMCID: PMC4738143

PMID: 26692448

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https://doi.org/10.1037/bne0000117View

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Abstract

Previous studies showed that the anterior cingulate cortex (ACC) plays a role in selective visual attention. The current study further examined the role of the ACC in attention using a visual cuing task with task-relevant and task-irrelevant stimuli. On every trial, 2 stimuli were presented on the touchscreen; 1 was task-relevant and the other was task-irrelevant. Rats were trained to attend to the task-relevant stimulus over the task-irrelevant stimulus to determine which side of the touchscreen should be selected for reward. After the rats were well-trained, cannulas targeting the ACC were implanted bilaterally for infusions of PBS or muscimol. When the ACC was functionally intact, high task performance was correlated with the anticipatory touches toward the reward; rats touched the stimulus proximal to the correct side more often, regardless of its task-relevancy. Analysis of the presurgery training data showed that rats developed anticipatory touches during training. Linear discriminant analyses of the touches also showed that the touches predict rats' choices in trials. With muscimol infusions, choice accuracy was impaired and the anticipatory touches toward the correct response location were less frequent. A control experiment, in which there were no irrelevant stimuli, showed no effects of ACC inactivation on choice accuracy or anticipatory touches. These results indicate that the rat ACC plays a critical role in reducing distraction from irrelevant stimuli as well as in guiding attention toward the goal locations.

Cues

Muscimol - pharmacology

Rats, Long-Evans

Memory, Episodic

Rats

Male

Functional Laterality

Touch

Animals

Memory Disorders - etiology

Analysis of Variance

GABA-A Receptor Agonists - pharmacology

Reaction Time - drug effects

Attention Deficit Disorder with Hyperactivity - etiology

Gyrus Cinguli - physiology

Gyrus Cinguli - drug effects

Reward

Photic Stimulation

Details

Title: Subtitle: Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory
Creators: Jangjin Kim - Department of Psychological and Brain Sciences, University of Iowa
Edward A Wasserman - Department of Psychological and Brain Sciences, University of Iowa
Leyre Castro - Department of Psychological and Brain Sciences, University of Iowa
John H Freeman - Department of Psychological and Brain Sciences, University of Iowa
Resource Type: Journal article
Publication Details: Behavioral neuroscience, Vol.130(1), pp.75-90
Publisher: United States
DOI: 10.1037/bne0000117
PMID: 26692448
PMCID: PMC4738143
ISSN: 0735-7044
eISSN: 1939-0084
Grant note: R01 MH080005 / NIMH NIH HHS MH080005 / NIMH NIH HHS R01 NS088567 / NINDS NIH HHS
Language: English
Date published: 02/2016
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065753602771

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