Journal article
Anterior ischemic optic neuropathy. IX. Cup-to-disc ratio and its role in pathogenesis
Ophthalmology (Rochester, Minn.), Vol.94(11), pp.1503-1508
11/1987
DOI: 10.1016/S0161-6420(87)33263-4
PMID: 3684223
Abstract
The optic disc appearance in the normal fellow eye of 126 patients with nonarteritic anterior ischemic optic neuropathy (n-AION) was compared with the discs in 23 patients with arteritic AION (a-AION) and 122 normal subjects. The number of discs with no cup was significantly greater (P less than 0.001) and the number of discs with a large cup was significantly fewer (P less than 0.001) in the n-AION group compared to the other two groups. No significant differences were found in cup size between the a-AION and normal groups. The pathogenesis of n-AION appears to be multifactorial. There is overwhelming evidence that ischemia is the primary factor. The size of the optic disc also plays a role, probably through a compressive effect at the level of the lamina cribrosa on axons subjected to ischemia. In contrast, a-AION occurs from posterior ciliary artery occlusion and disc size is not a factor.
Details
- Title: Subtitle
- Anterior ischemic optic neuropathy. IX. Cup-to-disc ratio and its role in pathogenesis
- Creators
- R W Beck - University of Michigan–Ann ArborG E Servais - University of IowaS S Hayreh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.94(11), pp.1503-1508
- DOI
- 10.1016/S0161-6420(87)33263-4
- PMID
- 3684223
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Grant note
- EY-1151 / NEI NIH HHS
- Language
- English
- Date published
- 11/1987
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984182970002771
Metrics
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