Journal article
Anteroventral bed nuclei of the stria terminalis neurocircuitry: Towards an integration of HPA axis modulation with coping behaviors - Curt Richter Award Paper 2017
Psychoneuroendocrinology, Vol.89, pp.239-249
03/2018
DOI: 10.1016/j.psyneuen.2017.12.005
PMCID: PMC5878723
PMID: 29395488
Abstract
A network of interconnected cell groups in the limbic forebrain regulates hypothalamic-pituitary-adrenal (HPA) axis activation and behavioral responses to emotionally stressful experiences, and chronic disruption of these systems chronically is implicated in the pathogenesis of psychiatric illnesses. A significant challenge has been to unravel the circuitry and mechanisms providing for regulation of HPA activity, as these limbic forebrain regions do not provide any direct innervation of HPA effector cell groups in the paraventricular hypothalamus (PVH). Moreover, information regarding how endocrine and behavioral responses are integrated has remained obscure. Here we summarize work from our laboratory showing that anteroventral (av) bed nuclei of the stria terminalis (BST) acts as a point of convergence between the limbic forebrain and PVH, receiving and coordinating upstream influences, and restraining HPA axis output in response to inescapable stressors. Recent studies highlight a more expansive modulatory role for avBST as one that coordinates HPA-inhibitory influences while concurrently suppressing passive behavioral responses via divergent pathways. avBST is uniquely positioned to convey endocrine and behavioral alterations resulting from chronic stress exposure, such as HPA axis hyperactivity and increased passive coping strategies, that may result from synaptic reorganization in upstream limbic cortical regions. We discuss how these studies give new insights into understanding the systems-level organization of stress response circuitry, the neurobiology of coping styles, and BST circuit dysfunction in stress-related psychiatric disorders.
Details
- Title: Subtitle
- Anteroventral bed nuclei of the stria terminalis neurocircuitry: Towards an integration of HPA axis modulation with coping behaviors - Curt Richter Award Paper 2017
- Creators
- Jason J Radley - Department of Psychological and Brain Sciences and Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, IA 52242, United States. Electronic address: Jason-Radley@uiowa.eduShane B Johnson - Department of Psychological and Brain Sciences and Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Psychoneuroendocrinology, Vol.89, pp.239-249
- DOI
- 10.1016/j.psyneuen.2017.12.005
- PMID
- 29395488
- PMCID
- PMC5878723
- NLM abbreviation
- Psychoneuroendocrinology
- ISSN
- 0306-4530
- eISSN
- 1873-3360
- Publisher
- England
- Grant note
- R01 MH119106 / NIMH NIH HHS R56 MH095972 / NIMH NIH HHS R01 MH095972 / NIMH NIH HHS
- Language
- English
- Date published
- 03/2018
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070517302771
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