Journal article
Anteroventral third ventricle lesions reduce antidiuretic responses to angiotensin II
The American journal of physiology, Vol.236(6), pp.E610-E615
06/1979
DOI: 10.1152/ajpendo.1979.236.6.e610
PMID: 443416
Abstract
Ablation of anteroventral third ventricle (AV3V) periventricular tissue renders animals temporarily adipsic with no compensatory change in urine volume or concentration. The present experiment was designed to determine whether lesions of the AV3V region attenuate vasopressin (AVP) release in response to intraventricular (ivt) injections of angiotensin II (AII), hypertonic NaCl, and phenylephrine during the adipsic period. Blood pressure, urine conductance, and urine flow rate were monitored in awake, unrestrained animals during a continuous intravenous hydrating infusion. Changes in blood pressure and urine parameters were recorded following ivt injections of 100 ng AII, 500 ng AII, 1 microliter 3% NaCl, and 50 microgram phenylephrine. In addition, a radioimmunoassay (RIA) measured AVP following 500 ng AII ivt in lesioned and nonlesioned animals. Antidiuretic and pressor responses to ivt AII were attenuated after AV3V lesions. In addition, RIA analysis showed a significantly smaller concentration of AVP in lesioned animals following AII injections. These data suggest that the AV3V region is important for AVP release in response to central AII and osmotic stimuli.
Details
- Title: Subtitle
- Anteroventral third ventricle lesions reduce antidiuretic responses to angiotensin II
- Creators
- Steven L BealerM. Ian PhillipsAlan Kim JohnsonPhillip G Schmid
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.236(6), pp.E610-E615
- DOI
- 10.1152/ajpendo.1979.236.6.e610
- PMID
- 443416
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Language
- English
- Date published
- 06/1979
- Academic Unit
- Psychological and Brain Sciences; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984213261702771
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