Anthropometric charts for infants with trisomies 21, 18, or 13 born between 22 weeks gestation and term: the VON charts

Nansi S Boghossian; Jeffrey D Horbar; Jeffrey C Murray; Joseph H Carpenter

doi:10.1002/ajmg.a.34423

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Anthropometric charts for infants with trisomies 21, 18, or 13 born between 22 weeks gestation and term: the VON charts

Journal article

Peer reviewed

Anthropometric charts for infants with trisomies 21, 18, or 13 born between 22 weeks gestation and term: the VON charts

Nansi S Boghossian, Jeffrey D Horbar, Jeffrey C Murray and Joseph H Carpenter

American journal of medical genetics. Part A, Vol.158A(2), pp.322-332

02/2012

DOI: 10.1002/ajmg.a.34423

PMCID: PMC3646092

PMID: 22246859

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Abstract

Data on birth weight for gestational age (GA) are not well described for infants with trisomy 21 (T21), trisomy 18 (T18), or trisomy 13 (T13). We report on anthropometric charts of infants with these conditions using data from the Vermont Oxford Network (VON). Data from a total of 5,147 infants with T21 aged 22-41 weeks, 1,053 infants with T18 aged 22-41 weeks, and 613 infants with T13 aged 22-40 weeks were used to create birth weight for GA charts. Head circumference for GA charts were created for infants with T21 only. Combined-sex charts were generated for infants with T18 or T13 while sex-specific charts were generated for infants with T21. Smoothed centiles were created using LmsChartMaker Pro 2.3. Among the three examined groups, infants with T18 were the most likely to be growth restricted while infants with T21 were the least likely to be growth restricted. The new charts for infants with T21 were also compared to the Lubchenco and Fenton charts and both show frequent misclassification of infants with T21 as small or large for GA. The new charts should prove to be useful, especially for infants with T21, to assist in medical management and guide nutrition care decisions.

Birth Weight

Trisomy - genetics

Cephalometry - methods

Humans

Female

Infant

Male

Trisomy - pathology

Chromosomes, Human, Pair 15 - genetics

Chromosomes, Human, Pair 18 - genetics

Chromosomes, Human, Pair 21 - genetics

Gestational Age

Details

Title: Subtitle: Anthropometric charts for infants with trisomies 21, 18, or 13 born between 22 weeks gestation and term: the VON charts
Creators: Nansi S Boghossian - Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA. nansi.boghossian@nih.gov
Jeffrey D Horbar
Jeffrey C Murray
Joseph H Carpenter
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part A, Vol.158A(2), pp.322-332
DOI: 10.1002/ajmg.a.34423
PMID: 22246859
PMCID: PMC3646092
NLM abbreviation: Am J Med Genet A
ISSN: 1552-4825
eISSN: 1552-4833
Publisher: United States
Grant note: R01 HD057192 / NICHD NIH HHS R01 HD052953 / NICHD NIH HHS
Language: English
Date published: 02/2012
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025336402771

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