Journal article
Anti-Cortactin Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis
Arthritis & rheumatology (Hoboken, N.J.), Vol.74(2), pp.358-364
02/2022
DOI: 10.1002/art.41931
PMCID: PMC8792092
PMID: 34313394
Abstract
To define the prevalence and clinical phenotype of anti-cortactin autoantibodies in adult and juvenile myositis.
In this longitudinal cohort study, anti-cortactin autoantibody titers were assessed by enzyme-linked immunosorbent assay in 670 adult myositis patients and 343 juvenile myositis patients as well as in 202 adult healthy controls and 90 juvenile healthy controls. The prevalence of anti-cortactin autoantibodies was compared among groups. Clinical features of patients with and those without anti-cortactin autoantibodies were also compared.
Anti-cortactin autoantibodies were more common in adult dermatomyositis (DM) patients (15%; P = 0.005), particularly those with coexisting anti-Mi-2 autoantibodies (24%; P = 0.03) or anti-NXP-2 autoantibodies (23%; P = 0.04). In adult myositis, anti-cortactin was associated with DM skin involvement (62% of patients with anti-cortactin versus 38% of patients without anti-cortactin; P = 0.03), dysphagia (36% versus 17%; P = 0.02) and coexisting anti-Ro 52 autoantibodies (47% versus 26%; P = 0.001) or anti-NT5c1a autoantibodies (59% versus 33%; P = 0.001). Moreover, the titers of anti-cortactin antibodies were higher in patients with interstitial lung disease (0.15 versus 0.12 arbitrary units; P = 0.03). The prevalence of anti-cortactin autoantibodies was not different in juvenile myositis patients (2%) or in any juvenile myositis subgroup compared to juvenile healthy controls (4%). Nonetheless, juvenile myositis patients with these autoantibodies had a higher prevalence of "mechanic's hands" (25% versus 7%; P = 0.03), a higher number of hospitalizations (2.9 versus 1.3; P = 0.04), and lower peak creatine kinase values (368 versus 818 IU/liter; P = 0.02) than those without anti-cortactin.
The prevalence of anti-cortactin autoantibodies is increased in adult DM patients with coexisting anti-Mi-2 or anti-NXP-2 autoantibodies. In adults, anti-cortactin autoantibodies are associated with dysphagia and interstitial lung disease.
Details
- Title: Subtitle
- Anti-Cortactin Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis
- Creators
- Iago Pinal-Fernandez - Johns Hopkins MedicineKatherine Pak - National Institute of Arthritis and Musculoskeletal and Skin DiseasesAlbert Gil-Vila - Universitat Autònoma de BarcelonaAndres Baucells - Hospital de Sant PauBenjamin Plotz - NYU Langone HealthMaria Casal-Dominguez - Johns Hopkins MedicineAssia Derfoul - National Institute of Arthritis and Musculoskeletal and Skin DiseasesMaria Angeles Martinez-Carretero - Sant Pau Hospital, Barcelona, SpainAlbert Selva-O'Callaghan - Universitat Autònoma de BarcelonaSara Sabbagh - Medical College of WisconsinLivia Casciola-Rosen - Johns Hopkins MedicineJemima Albayda - Johns Hopkins MedicineJulie Paik - Johns Hopkins MedicineEleni Tiniakou - Johns Hopkins MedicineSonye K Danoff - Johns Hopkins MedicineThomas E Lloyd - Johns Hopkins MedicineFrederick W Miller - National Institute of Environmental Health SciencesLisa G Rider - National Institute of Environmental Health SciencesLisa Christopher-Stine - Johns Hopkins MedicineAndrew L Mammen - National Institute of Arthritis and Musculoskeletal and Skin DiseasesChildhood Myositis Heterogeneity Collaborative Study Group
- Contributors
- Scott A Vogelgesang (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Arthritis & rheumatology (Hoboken, N.J.), Vol.74(2), pp.358-364
- DOI
- 10.1002/art.41931
- PMID
- 34313394
- PMCID
- PMC8792092
- NLM abbreviation
- Arthritis Rheumatol
- ISSN
- 2326-5191
- eISSN
- 2326-5205
- Grant note
- Myositis Association NIEHS NIH HHS ZIA AR041203 / Intramural NIH HHS NIAMS NIH HHS
- Language
- English
- Date published
- 02/2022
- Academic Unit
- Immunology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984360043502771
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