Journal article
Anti-diabetic activity of Vaccinium bracteatum Thunb. leaves’ polysaccharide in STZ-induced diabetic mice
International journal of biological macromolecules, Vol.61, pp.317-321
10/01/2013
DOI: 10.1016/j.ijbiomac.2013.07.028
PMID: 23916645
Abstract
Vaccinium bracteatum Thunb. (VBT) is a traditional Chinese herbal medicine. The anti-diabetic activity of VBT leaves’ polysaccharide (VBTLP) is studied in this paper. The results indicated VBTLP had a dose-dependent decrease on the blood glucose (BG) level, and the time effect of VBTLP on BG level was also significant. The insulin level of high dose group (HDG) was significantly higher (p<0.05) than that of model control (MC) group. Compared to MC, HDG and lose dose group (LDG) had significantly lower (p<0.05) TC and LDL-C levels, however, TG and HDL-C levels are similar. Compared to non-diabetic control (NC), HDG and LDG had similar plasma lipid levels except for higher LDL-C level. Although body weights of LDG and HDG were significant lower (p<0.05) than that of NC from week 2 to week 6, they were similar to that of PC. The results indicate VBTLP possesses a potential hypoglycemic effect in streptozotocin-induced diabetic mice.
Details
- Title: Subtitle
- Anti-diabetic activity of Vaccinium bracteatum Thunb. leaves’ polysaccharide in STZ-induced diabetic mice
- Creators
- Li Wang - Jiangnan UniversityYing Zhang - China National Research Institute of Food and FermentationMaochao Xu - Illinois State UniversityYingyao Wang - Academy of State Administration of GrainSujiao Cheng - Jiangnan UniversityAlex Liebrecht - Illinois State UniversityHaifeng Qian - Jiangnan UniversityHui Zhang - Jiangnan UniversityXiguang Qi - Jiangnan University
- Resource Type
- Journal article
- Publication Details
- International journal of biological macromolecules, Vol.61, pp.317-321
- DOI
- 10.1016/j.ijbiomac.2013.07.028
- PMID
- 23916645
- NLM abbreviation
- Int J Biol Macromol
- ISSN
- 0141-8130
- eISSN
- 1879-0003
- Publisher
- Elsevier B.V
- Number of pages
- 5
- Language
- English
- Date published
- 10/01/2013
- Academic Unit
- Statistics and Actuarial Science
- Record Identifier
- 9984936618002771
Metrics
8 Record Views