Journal article
Anti-inflammatory drug releasing absorbable surgical sutures using poly(lactic-co-glycolic acid) particle carriers
Polymer bulletin (Berlin, Germany), Vol.71(8), pp.1933-1946
08/01/2014
DOI: 10.1007/s00289-014-1164-8
Abstract
The goal of the current study was to develop an absorbable surgical suture incorporating poly(lactic-co-glycolic acid) (PLGA) particles loaded with dexamethasone (DEX) as an anti-inflammatory drug. DEX-loaded PLGA (DEX/PLGA) particles, prepared using a water-in-oil emulsion method, were electrostatically immobilized onto the surface of absorbable sutures. The surfaces of these DEX/PLGA particles were coated with positively charged polyethyleneimine (PEI) molecules, which imparted a net positive surface charge. These modified PEI-coated DEX/PLGA (PEI/DEX/PLGA) particles were then immobilized on negatively charged absorbable suture surfaces by electrostatic attraction. The results showed that DEX was efficiently loaded into PLGA particles and that the surfaces of DEX/PLGA particles were successfully coated with PEI. PEI/DEX/PLGA particles were well dispersed and immobilized onto suture surfaces. In addition, PEI/DEX/PLGA particles remained adherent to suture surfaces in vitro and demonstrated sustained DEX release in phosphate-buffered saline (pH 7.4) at 37 A degrees C for up to 28 days under static conditions. The tensile strength and elongation at break of PEI/DEX/PLGA particle-treated sutures were almost the same as that of non-treated control sutures. Findings of this study show that various therapeutic drugs could be efficiently incorporated into absorbable sutures using biodegradable polymeric particles, and suggest that the devised absorbable, drug-eluting, sutures offer a promising basis for a novel absorbable surgical suture system.
Details
- Title: Subtitle
- Anti-inflammatory drug releasing absorbable surgical sutures using poly(lactic-co-glycolic acid) particle carriers
- Creators
- Du-Hyeong Lee - Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Taegu 700412, South KoreaTae-Yub Kwon - Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, Taegu 700412, South KoreaKyo-Han Kim - Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, Taegu 700412, South KoreaSoon-Taek Kwon - Korea Development InstituteDae-Hyun Cho - Korea Text Dev Inst, Taegu 703712, South KoreaSoon Ho Jang - Korea Development InstituteJun Sik Son - Korea Development InstituteKyu-Bok Lee - Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Taegu 700412, South Korea
- Resource Type
- Journal article
- Publication Details
- Polymer bulletin (Berlin, Germany), Vol.71(8), pp.1933-1946
- DOI
- 10.1007/s00289-014-1164-8
- ISSN
- 0170-0839
- eISSN
- 1436-2449
- Publisher
- Springer Nature
- Number of pages
- 14
- Grant note
- 11-06 / Biomedical Research Institute Grant, Kyungpook National University Hospital
- Language
- English
- Date published
- 08/01/2014
- Academic Unit
- Prosthodontics
- Record Identifier
- 9984914019702771
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