Journal article
Anti-inflammatory medication use associated with reduced delirium risk and all-cause mortality: A retrospective cohort study
Journal of psychosomatic research, Vol.168, 111212
03/12/2023
DOI: 10.1016/j.jpsychores.2023.111212
PMID: 36963165
Abstract
To investigate the relationship between history of anti-inflammatory medication use and delirium risk, as well as long-term mortality.
In this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Information about anti-inflammatory medication use history including aspirin, NSAIDs, glucosamine, and other anti-inflammatory drugs, was collected. Logistic regression analysis investigated the relationship between anti-inflammatory medications and delirium. Log-rank analysis and cox proportional hazards model investigated the relationship between anti-inflammatory medications and one-year mortality.
The data from 1274 subjects were analyzed. The prevalence of delirium was significantly lower in subjects with NSAIDs usage (23.0%) than in those without NSAIDs usage (35.0%) (p < 0.001). Logistic regression analysis controlling for age, sex, dementia status, and hospitalization department showed that the risk of delirium tended to be reduced by a history of NSAIDs use (OR, 0.76 [95% CI, 0.55 to 1.03]). The one-year mortality in the subjects with NSAIDs (survival rate, 0.879 [95% CI, 0.845 to 0.906]) was significantly higher than in the subjects without NSAIDs (survival rate, 0.776 [95% CI, 0.746 to 0.803]) (p < 0.001). A history of NSAIDs use associated with the decreased risk of one-year mortality even after adjustment for age, sex, Charlson Comorbidity Index, delirium status, and hospitalization department (HR, 0.70 [95% CI, 0.51 to 0.96]).
This study suggested that NSAIDs usage was associated with decreased delirium prevalence and lower one-year mortality. The potential benefit of NSAIDs on delirium risk and mortality were shown.
Details
- Title: Subtitle
- Anti-inflammatory medication use associated with reduced delirium risk and all-cause mortality: A retrospective cohort study
- Creators
- Takehiko YamanashiEleanor J Sullivan - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaKatie R Comp - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaYoshitaka NishizawaCade C Akers - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaGloria Chang - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaManisha Modukuri - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaTammy Tran - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaZoe-Ella E M Anderson - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaPedro S Marra - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaKaitlyn J Crutchley - University of IowaNadia E Wahba - University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United States of AmericaMasaaki Iwata - Tottori UniversityMatthew D Karam - University of IowaNicolas O Noiseux - University of IowaHyunkeun R Cho - University of IowaGen Shinozaki
- Resource Type
- Journal article
- Publication Details
- Journal of psychosomatic research, Vol.168, 111212
- DOI
- 10.1016/j.jpsychores.2023.111212
- PMID
- 36963165
- ISSN
- 0022-3999
- eISSN
- 1879-1360
- Language
- English
- Date published
- 03/12/2023
- Academic Unit
- Psychiatry; Biostatistics; Orthopedics and Rehabilitation; Neurosurgery
- Record Identifier
- 9984380372002771
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