Journal article
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models
European journal of pharmacology, Vol.708(1-3), pp.80-87
05/15/2013
DOI: 10.1016/j.ejphar.2013.03.036
PMID: 23545357
Abstract
In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models. The anti-nociceptive activity of aliskiren was investigated in chemically-induced pain, orofacial pain and centrally mediated pain models. Anti-allodynic activity was evaluated in post-operative and neuropathic pain models. The levels of TNF-α and IL-6 were measured in homogenates of hind paw as markers of inflammation in formalin injected mice. Intraperitoneal administration of aliskiren (1–50mg/kg) showed anti-nociceptive activity in the writhing test, formalin hind paw test, capsaicin induced pain, and orofacial pain tests in ICR mice in a dose dependent manner. Aliskiren (50mg/kg, i.p.) reduced levels of TNF-α and IL-6 in hind paw homogenates of formalin-injected mice. Aliskiren (50mg/kg, i.p.) did not show any analgesic activity in hot-plate and tail-flick tests, indicating the absence of centrally mediated anti-nociceptive effects. On the other hand, intra-plantar administration of aliskiren (0.1, 0.5 and 1mg) showed analgesic activity in rat formalin tests, indicating a locally mediated effect. Aliskiren (30–100mg/kg, i.p.) showed anti-allodynic activity in post-operative pain and chronic constriction injury-induced neuropathic pain in Sprague Dawley rats. This data suggests that aliskiren may have the potential to be used as an anti-nociceptive and anti-allodynic agent.
Details
- Title: Subtitle
- Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models
- Creators
- Rakesh B. Patel - Cadila Healthcare (India)Vishwanath D. Pawar - Cadila Healthcare (India)Kanaiyalal D. Prajapati - Cadila Healthcare (India)Bhavin M. Sonara - Cadila Healthcare (India)Shrikalp S. Deshpande - K.B. Institute of Pharmaceutical Education and Research, Sector-23, Gandhinagar 382 023, Gujarat, IndiaGaurang B. Shah - K.B. Institute of Pharmaceutical Education and Research, Sector-23, Gandhinagar 382 023, Gujarat, IndiaMukul R. Jain - Cadila Healthcare (India)
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.708(1-3), pp.80-87
- DOI
- 10.1016/j.ejphar.2013.03.036
- PMID
- 23545357
- NLM abbreviation
- Eur J Pharmacol
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Publisher
- Elsevier B.V
- Number of pages
- 8
- Language
- English
- Date published
- 05/15/2013
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985132070802771
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