Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

Moon Ley Tung; Bryce Tan; Robin Cherian; Bharatendu Chandra

doi:10.1093/rap/rkaa081

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Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

Journal article

Open access

Peer reviewed

Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

Moon Ley Tung, Bryce Tan, Robin Cherian and Bharatendu Chandra

Rheumatology advances in practice, Vol.5(1), pp.rkaa081-rkaa081

2021

DOI: 10.1093/rap/rkaa081

PMCID: PMC7882149

PMID: 33615129

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Abstract

As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it has emerged as a leading cause of mortality, resulting in >1 million deaths over the past 10 months. The pathophysiology of COVID-19 remains unclear, posing a great challenge to the medical management of patients. Recent studies have reported an unusually high prevalence of thromboembolic events in COVID-19 patients, although the mechanism remains elusive. Several studies have reported the presence of aPLs in COVID-19 patients. We have noticed similarities between COVID-19 and APS, which is an autoimmune prothrombotic disease that is often associated with an infective aetiology. Molecular mimicry and endothelial dysfunction could plausibly explain the mechanism of thrombogenesis in acquired APS. In this review, we discuss the clinicopathological similarities between COVID-19 and APS, and the potential role of therapeutic targets based on the anti-phospholipid model for COVID-19 disease.

COVID-19

molecular mimicry

thrombosis

autoimmunity

anticoagulation

anti-phospholipid antibodies

anti-phospholipid syndrome

oxidative stress

Details

Title: Subtitle: Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots
Creators: Moon Ley Tung - National University of Singapore
Bryce Tan - Department of Medicine, National University Hospital
Robin Cherian - National University of Singapore
Bharatendu Chandra - Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore
Resource Type: Journal article
Publication Details: Rheumatology advances in practice, Vol.5(1), pp.rkaa081-rkaa081
DOI: 10.1093/rap/rkaa081
PMID: 33615129
PMCID: PMC7882149
NLM abbreviation: Rheumatol Adv Pract
ISSN: 2514-1775
eISSN: 2514-1775
Language: English
Date published: 2021
Academic Unit: Stead Family Department of Pediatrics; Medical Genetics and Genomics
Record Identifier: 9984353949602771

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