Journal article
Anti–Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients
The Journal of infectious diseases, Vol.223(3), pp.517-521
07/02/2020
DOI: 10.1093/infdis/jiaa381
PMCID: PMC7881328
PMID: 32614452
Abstract
Visceral leishmaniasis (VL;
Leishmania donovani
) cases produce interferon-γ and tumor necrosis factor in response to soluble leishmanial antigen (SLA) in whole-blood assays. Using transcriptional profiling, we demonstrate the impact of interleukin-10 (IL-10), a cytokine implicated in VL, on this response. SLA stimulation identified 28 differentially expressed genes (DEGs), 17/28 in a single network with
TNF
as hub. SLA plus anti–IL-10 produced 454 DEGs, 292 in a single network with
TNF
,
IFNG
,
NFKBIA
,
IL6,
and
IL1B
as hubs in concert with a remarkable chemokine/cytokine storm. Our data demonstrate the singular effect of IL-10 as a potent immune modulator in VL.
Details
- Title: Subtitle
- Anti–Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients
- Creators
- Om Prakash Singh - , Varanasi, Uttar Pradesh, , Varanasi, Uttar Pradesh, , Nedlands, Western Australia, , Stockholm, , Brisbane, , Bethesda, Maryland, , Iowa City, Iowa, , Varanasi, Uttar Pradesh, , Cambridge, MilanGenevieve Syn - Telethon Kids InstituteSusanne Nylén - Karolinska InstitutetChristian Engwerda - QIMR Berghofer Medical Research InstituteDavid Sacks - National Institute of Allergy and Infectious DiseasesMary E Wilson - University of IowaRajiv Kumar - Banaras Hindu UniversityJaya Chakravarty - Banaras Hindu UniversityShyam Sundar - Banaras Hindu UniversityJenefer M Blackwell - Telethon Kids InstituteMichaela Fakiola - University of Cambridge
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.223(3), pp.517-521
- Publisher
- Oxford University Press
- DOI
- 10.1093/infdis/jiaa381
- PMID
- 32614452
- PMCID
- PMC7881328
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Grant note
- U19 AI074321 / ; ;
- Language
- English
- Date published
- 07/02/2020
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984297424002771
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