Journal article
Antibacterial Activity of Crotalid Venoms against Oral Snake Flora and Other Clinical Bacteria
The Journal of infectious diseases, Vol.164(1), pp.195-198
07/1991
DOI: 10.1093/infdis/164.1.195
PMID: 2056205
Abstract
Despite heavy oral and fang contamination of crotalid species with a wide variety of potentially pathogenic bacteria, crotalid envenomation is associated with a low incidence of bacterial infection. Minimal inhibitory and bactericidal concentrations of venoms from three crotalid species were determined against six aerobic and eight anaerobic reference and oral crotalid microorganisms. All anaerobic isolates were resistant to >20,480 µg/ml, whereas variable activity (range, 5–20,480 µg/ml) was observed for aerobic strains. Further studies against other aerobic clinical isolates demonstrated that venom had the greatest activity (MIC, ⩽80 µg/ml) against staphylococci, Pseudomonas aeruginosa, and Enterobacter, Citrobacter, Proteus, and Morganella species. Inhibitory activity was lost with prolonged incubation for many gram-negative species. Crotalid venoms are broadly active against aerobic gram-negative and -positive bacteria. This activity may playa role in the low incidence of infection after envenomation injuries
Details
- Title: Subtitle
- Antibacterial Activity of Crotalid Venoms against Oral Snake Flora and Other Clinical Bacteria
- Creators
- David A. Talan - Olive View-UCLA Medical CenterDiane M. Citron - Departments of Emergency Medicine and Pediatrics, UCLA Olive View Medical Center, Sylmar, CaliforniaGary D. Overturf - Departments of Emergency Medicine and Pediatrics, UCLA Olive View Medical Center, Sylmar, CaliforniaBret Singer - Departments of Emergency Medicine and Pediatrics, UCLA Olive View Medical Center, Sylmar, CaliforniaPhilip Froman - Departments of Emergency Medicine and Pediatrics, UCLA Olive View Medical Center, Sylmar, CaliforniaEllie J. C. Goldstein - Departments of Emergency Medicine and Pediatrics, UCLA Olive View Medical Center, Sylmar, California
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.164(1), pp.195-198
- Publisher
- The University of Chicago Press
- DOI
- 10.1093/infdis/164.1.195
- PMID
- 2056205
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 07/1991
- Academic Unit
- Emergency Medicine; Internal Medicine
- Record Identifier
- 9984296970302771
Metrics
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