Journal article
Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects
Pharmaceuticals (Basel, Switzerland), Vol.13(10), pp.304-12
10/12/2020
DOI: 10.3390/ph13100304
PMCID: PMC7600417
PMID: 33053829
Abstract
Polymers are the most commonly used material for three-dimensional (3D) printing in dentistry; however, the high porosity and water absorptiveness of the material adversely influence biofilm formation on the surface of the 3D-printed dental prostheses. This study evaluated the effects of a newly developed chlorhexidine (CHX)-loaded polydimethylsiloxane (PDMS)-based coating material on the surface microstructure, surface wettability and antibacterial activity of 3D-printing dental polymer. First, mesoporous silica nanoparticles (MSN) were used to encapsulate CHX, and the combination was added to PDMS to synthesize the antibacterial agent-releasing coating substance. Then, a thin coating film was formed on the 3D-printing polymer specimens using oxygen plasma and thermal treatment. The results show that using the coating substance significantly reduced the surface irregularity and increased the hydrophobicity of the specimens. Remarkably, the culture media containing coated specimens had a significantly lower number of bacterial colony formation units than the noncoated specimens, thereby indicating the effective antibacterial activity of the coating.
Details
- Title: Subtitle
- Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects
- Creators
- Hang-Nga Mai - Kyungpook Natl Univ, Inst Translat Res Dent, Daegu 41940, South KoreaDong Choon Hyun - Kyungpook National UniversityJu Hayng Park - Kyungpook National UniversityDo-Yeon Kim - Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South KoreaSang Min Lee - Kyungpook National UniversityDu-Hyeong Lee - Kyungpook Natl Univ, Inst Translat Res Dent, Daegu 41940, South Korea
- Resource Type
- Journal article
- Publication Details
- Pharmaceuticals (Basel, Switzerland), Vol.13(10), pp.304-12
- DOI
- 10.3390/ph13100304
- PMID
- 33053829
- PMCID
- PMC7600417
- NLM abbreviation
- Pharmaceuticals (Basel)
- ISSN
- 1424-8247
- eISSN
- 1424-8247
- Publisher
- Mdpi
- Number of pages
- 12
- Grant note
- 2020R1A2C4002518 / National Research Foundation of Korea (NRF) - Korea government (MSIT); National Research Foundation of Korea; Ministry of Science, ICT & Future Planning, Republic of Korea; Ministry of Science & ICT (MSIT), Republic of Korea
- Language
- English
- Date published
- 10/12/2020
- Academic Unit
- Prosthodontics
- Record Identifier
- 9984914019002771
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