Antibiotic Recommendations for Treatment of Canine Stromal Corneal Ulcers

Milan Joksimovic; Bradley A. Ford; Tatjana Lazic; Ivan Soldatovic; Sergey Luzetsky; Sinisa Grozdanic

doi:10.3390/vetsci10020066

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Antibiotic Recommendations for Treatment of Canine Stromal Corneal Ulcers

Journal article

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Antibiotic Recommendations for Treatment of Canine Stromal Corneal Ulcers

Milan Joksimovic, Bradley A. Ford, Tatjana Lazic, Ivan Soldatovic, Sergey Luzetsky and Sinisa Grozdanic

Veterinary sciences, Vol.10(2), p.66

01/17/2023

DOI: 10.3390/vetsci10020066

PMCID: PMC9962943

PMID: 36851370

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Abstract

The aim of the study was to identify the aerobic bacterial isolates and determine corresponding antibiotic susceptibility profiles in vitro in canine clinical specimens with stromal corneal ulcers, with the goal of providing recommendations for first-line treatment with antibiotics. A total of 198 canine corneal stromal ulcer samples were studied between 2018 and 2021. A corneal swab was collected and cultured under aerobic conditions. Bacterial organisms were identified at the species level by MALDI-TOF mass spectrometry. Antibiotic susceptibility testing for commonly used topical and systemic antibiotics was performed by disk diffusion. Bacterial growth was obtained from 80% of samples. A variety of bacterial species were identified wherein the most common specimens were represented by Staphylococcus pseudintermedius (22%), Staphylococcus epidermidis (12%), Staphylococcus capitis (11%), and Pseudomonas aeruginosa (10%). Based on the overall antibiotic susceptibility data, neopolybac alone (96%) or a combination of neopolybac with either ofloxacin or amikacin (each 99%) showed the best coverage for commonly isolated bacterial organisms from canine corneal stromal ulcers. Results of this study support the use of the combined antibiotics as the first-line response for the treatment of canine corneal stromal ulcers. A statically significant increase in acquired bacterial resistance was detected during the longitudinal data observation.

Details

Title: Subtitle: Antibiotic Recommendations for Treatment of Canine Stromal Corneal Ulcers
Creators: Milan Joksimovic - Ophthalmology Consultants
Bradley A. Ford
Tatjana Lazic
Ivan Soldatovic
Sergey Luzetsky
Sinisa Grozdanic
Resource Type: Journal article
Publication Details: Veterinary sciences, Vol.10(2), p.66
DOI: 10.3390/vetsci10020066
PMID: 36851370
PMCID: PMC9962943
NLM abbreviation: Vet Sci
ISSN: 2306-7381
eISSN: 2306-7381
Language: English
Date published: 01/17/2023
Academic Unit: Pathology
Record Identifier: 9984363380402771

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