Antibiotic use for asymptomatic bacteriuria in children with neurogenic bladder

Azadeh Wickham; Susan F McElroy; Lindsey Austenfeld; J Hogan Randall; Alonso Carrasco; Gina Weddle; Paul Bowlin; Joel Koenig; John M Gatti

doi:10.3233/PRM-210051

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Antibiotic use for asymptomatic bacteriuria in children with neurogenic bladder

Journal article

Peer reviewed

Antibiotic use for asymptomatic bacteriuria in children with neurogenic bladder

Azadeh Wickham, Susan F McElroy, Lindsey Austenfeld, J Hogan Randall, Alonso Carrasco, Gina Weddle, Paul Bowlin, Joel Koenig and John M Gatti

Journal of pediatric rehabilitation medicine, Vol.15(4), pp.633-638

01/01/2022

DOI: 10.3233/PRM-210051

PMID: 36314224

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Abstract

Patients with neurogenic bladder (NB) often perform clean intermittent catheterization (CIC) and are predisposed to bladder colonization. Antibiotics are not routinely indicated in those with asymptomatic bacteriuria (ASB). The original purpose of this study was to compare patients that received antibiotics for ASB and those that did not. However, because the non-antibiotic group was very small, the final analysis evaluated treatment patterns of ASB in children with NB. A retrospective chart review was completed, including patients who presented with urinary tract infection (UTI) and NB managed by CIC. Patients with symptoms of UTI were excluded. Basic demographics, urinalysis, culture results, and antibiotic prescriptions were collected. The sample included 272 patient encounters for 109 unique patients. Of these, 50.7% were female, and the median age was 10.25 years. More than half the urine cultures (56.2%) grew gram-negative organisms, and 31.3% contained 2 or more organisms. Nearly all encounters received treatment with antibiotics. Twenty-three encounters with no culture performed or the culture resulted in no growth received antibiotic therapy. Antibiotic resistance and antibiotic stewardship are primary concerns in healthcare today. This organization's current practice pattern shows high antibiotic use for ASB in patients with NB. Future studies are required to identify outcomes associated with treatment versus non-treatment in these patients.

Anti-Bacterial Agents - therapeutic use

Bacteriuria - diagnosis

Bacteriuria - drug therapy

Bacteriuria - etiology

Child

Female

Humans

Male

Retrospective Studies

Urinary Bladder, Neurogenic - complications

Urinary Bladder, Neurogenic - drug therapy

Urinary Tract Infections - complications

Urinary Tract Infections - diagnosis

Urinary Tract Infections - drug therapy

Details

Title: Subtitle: Antibiotic use for asymptomatic bacteriuria in children with neurogenic bladder
Creators: Azadeh Wickham - Children's Mercy Hospital
Susan F McElroy - Children's Mercy Hospital
Lindsey Austenfeld - Children's Mercy Hospital
J Hogan Randall - University of Kansas Medical Center
Alonso Carrasco - Children's Mercy Hospital
Gina Weddle - Children's Mercy Hospital
Paul Bowlin - Children's Mercy Hospital
Joel Koenig - Children's Mercy Hospital
John M Gatti - Children's Mercy Hospital
Resource Type: Journal article
Publication Details: Journal of pediatric rehabilitation medicine, Vol.15(4), pp.633-638
DOI: 10.3233/PRM-210051
PMID: 36314224
NLM abbreviation: J Pediatr Rehabil Med
ISSN: 1874-5393
eISSN: 1875-8894
Language: English
Date published: 01/01/2022
Academic Unit: Urology
Record Identifier: 9984848502302771

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