Journal article
Antibodies to hepatitis C and other viral markersin multi-transfused patients from Argentina
Journal of clinical virology, Vol.34, pp.S20-S26
2005
DOI: 10.1016/S1386-6532(05)80030-7
PMID: 16461236
Abstract
Background: The knowledge of transfusion-transmitted viral infections in Argentina is scarce. A regional study organized by thePan American Health Organization let us asses the current status.
Objectives: To estimate the prevalence of HCV, HBV and HIV infection in a population of multi-transfused Argentinean patients.
Study design: Multi-center, cross sectional study of 504 patients from national referral institutions in Buenos Aires, who had received more than ten units of blood products in more than two occasions. Demographic and clinical data were collected using a standardized questionnaire. Blood samples were analyzed for a-HCV, a-HIV, HBsAg and a-HBcore.
Results: Patients belonged to five diagnostic categories: onco-hematology (309; 61.3%); hemophilia (96; 19%); acute bloodloss (54; 10.7% ); hemoglobinopathies (35; 6.9%); and hemodialysis (5; 1% ); five patients (1%) had two of the previous conditions. Overall prevalence rates of viral markers were: a-HCV 9.3% (CI
95%: 6.7–12.0); a-HBcore 4.8% (CI
95: 2.8–6.7); a-HIV 1.2% (CI
95%: 0.14–2.2) and HBsAg 0.20%(CI
95%: 0.2–0.59). The highest prevalence rates were found among patients living with hemophilia (PLH). There was a significant statistical association (p < 10
−5, OR =78.8 [29.7–209.7]) between a-HCV infection and having been transfused before 1993, when screening blood donors for a-HCV became mandatory in our country. The subpopulation of patients exposed to transfusion before 1993 was conformed mostly by PLH (70.9%) and hemoglobinopathies (18.6%). In this subpopulation, we found a significant association (p < 10
⃜, OR -40 [5.68–281.66]) between years of exposure to transfusion and a-HCV among the patients under the median age (21.95 years old); however, there was no association for those above the median age (p=0.111).
Conclusion: a-HCV was found to be the most prevalent infection in the multi-transfused patient population under study. Most infected individuals were PLH, transfused before 1993. This study will provide support for further research aimed at improving blood safety in Argentina.
Details
- Title: Subtitle
- Antibodies to hepatitis C and other viral markersin multi-transfused patients from Argentina
- Creators
- Mirta Remesar - Servicio de Hemoterapia, Hospital Nacional de Pediatria Prof. Dr. J.P. Garrahan, Combate de los Pozos 1881, Buenos Aires, ArgentinaCecilia Gamba - Servicio de Hemoterapia, Hospital Nacional de Pediatria Prof. Dr. J.P. Garrahan, Combate de los Pozos 1881, Buenos Aires, ArgentinaSilvina Kuperman - Servicio de Hemoterapia, Hospital Nacional de Pediatria Prof. Dr. J.P. Garrahan, Combate de los Pozos 1881, Buenos Aires, ArgentinaMaría Angélica Marcosa - Servicio de Hemoterapia, Hospital Nacional de Pediatria Prof. Dr. J.P. Garrahan, Combate de los Pozos 1881, Buenos Aires, ArgentinaGabriela MiguezSergio Caldarola - Servicio de Hemoterapia, Hospital Nacional Prof. Dr. A. Posadas, Pte. Illia s/N y Marconi, Haedo, Pcia. Buenos Aires, ArgentinaRaúl Pérez-Bianco - Academia Nacional de Medicina, Pacheco de Melo 3081, Buenos Aires, ArgentinaAlberto Manterola - Epidemiologia, Hospital Nacional de Pediatria Prof. Dr. J.P. Garrahan, Combate de los Pozos 1881, Buenos Aires, ArgentinaAna del Pozo - Servicio de Hemoterapia, Hospital Nacional de Pediatria Prof. Dr. J.P. Garrahan, Combate de los Pozos 1881, Buenos Aires, Argentina
- Resource Type
- Journal article
- Publication Details
- Journal of clinical virology, Vol.34, pp.S20-S26
- DOI
- 10.1016/S1386-6532(05)80030-7
- PMID
- 16461236
- NLM abbreviation
- J Clin Virol
- ISSN
- 1386-6532
- eISSN
- 1873-5967
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2005
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984004098602771
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