Journal article
Antibody response, neutralizing potency, and transplacental antibody transfer following SARS-CoV-2 infection versus mRNA-1273, BNT162b2 COVID-19 vaccination in pregnancy
International journal of gynecology and obstetrics, Vol.162(1), pp.154-162
07/2023
DOI: 10.1002/ijgo.14648
PMID: 36598270
Abstract
To improve our understanding of the immune response, including the neutralization antibody response, following COVID-19 vaccination in pregnancy.
This was a prospective cohort study comprising patients with PCR-confirmed SARS-CoV-2 infection and patients who received both doses of mRNA COVID-19 vaccine (mRNA-1273, BNT162b2) in pregnancy recruited from two hospitals in Atlanta, GA, USA. Maternal blood and cord blood at delivery were assayed for anti-receptor binding domain (RBD) IgG, IgA and IgM, and neutralizing antibody. The detection of antibodies, titers, and maternal to fetal transfer ratios were compared.
Nearly all patients had detectable RBD-binding IgG in maternal and cord samples. The vaccinated versus infected cohort had a significantly greater proportion of cord samples with detectable neutralizing antibody (94% vs. 28%, P < 0.001) and significantly higher transfer ratios for RBD-specific IgG and neutralizing antibodies with a transfer efficiency of 105% (vs. 80%, P < 0.001) and 110% (vs. 90%, P < 0.001), respectively. There was a significant linear decline in maternal and cord blood RBD-specific IgG and neutralizing antibody titers as time from vaccination to delivery increased.
Those who receive the mRNA COVID-19 vaccine mount an immune response that is equivalent to-if not greater than-those naturally infected by SARS-CoV-2 during pregnancy.
Details
- Title: Subtitle
- Antibody response, neutralizing potency, and transplacental antibody transfer following SARS-CoV-2 infection versus mRNA-1273, BNT162b2 COVID-19 vaccination in pregnancy
- Creators
- Carolynn M Dude - Emory UniversityNaima T Joseph - Beth Israel Deaconess Medical CenterAlexandra D Forrest - Emory UniversityHans P Verkerke - Brigham and Women's HospitalNarayanaiah Cheedarla - Emory UniversitySakthivel Govindaraj - Emory UniversityLes'Shon S Irby - Emory UniversityKirk A Easley - Emory UniversityAlicia K Smith - Emory UniversitySean R Stowell - Brigham and Women's HospitalAndrew Neish - Emory UniversityRama Rao Amara - Emory UniversityDenise J Jamieson - Emory UniversityAnne L Dunlop - Emory UniversityMartina L Badell - Emory UniversityVijayakumar Velu - Emory University
- Resource Type
- Journal article
- Publication Details
- International journal of gynecology and obstetrics, Vol.162(1), pp.154-162
- DOI
- 10.1002/ijgo.14648
- PMID
- 36598270
- ISSN
- 0020-7292
- eISSN
- 1879-3479
- Grant note
- P51 OD011132 / ODCDC CDC HHS P30 AI050409 / NIAID NIH HHS
- Language
- English
- Date published
- 07/2023
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446061602771
Metrics
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