Antibody response to pneumococcal vaccination as a function of preimmunization titer

Nathaniel D Hare; Brian J Smith; Zuhair K Ballas

doi:10.1016/j.jaci.2008.09.021

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Antibody response to pneumococcal vaccination as a function of preimmunization titer

Journal article

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Peer reviewed

Antibody response to pneumococcal vaccination as a function of preimmunization titer

Nathaniel D Hare, Brian J Smith and Zuhair K Ballas

Journal of allergy and clinical immunology, Vol.123(1), pp.195-200

2009

DOI: 10.1016/j.jaci.2008.09.021

PMCID: PMC3613280

PMID: 18951616

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Abstract

The interpretation of an adequate response to the unconjugated 23-valent pneumococcal vaccine for serotypes having high preimmunization titers remains challenging. We sought to determine whether high preimmunization titers preclude a 4-fold or greater response to vaccination. Moreover, we sought to determine the effect of the following covariates on this response: absolute preimmunization titer value, age, sex, serum IgG level, and serum IgG subclasses. We conducted a retrospective analysis of patients who were seen in our immune disorders clinic between 2001 and 2007 who had received the unconjugated 23-valent pneumococcal vaccine. Logistic regression was used to estimate the effect of different covariates, including preimmunization titer values, age, sex, IgG levels, and IgG subclass values, on the odds of a 4-fold or greater antibody response. Per serotype, 10% to 40% of subjects with a high preimmunization titer attained at least a 4-fold response to vaccination. However, the odds of a 4-fold or greater response were found to decrease as a function of the absolute preimmunization titer value with an absolute value for each serotype beyond which the odds ratio approached zero. High pneumococcal preimmunization titers do not necessarily preclude a 4-fold or greater response to vaccination. However, there appear to be serotype-specific preimmunization titer values, ranging from 4.4 to 10.3 μg/mL, above which a 4-fold or greater response would not be expected. This response does not seem to be significantly affected by age, sex, IgG level, or IgG subclass value.

antibody

IgG subclass

sex

high preimmunization titer

IgG

fold response

Pneumococcal vaccine

age

Details

Title: Subtitle: Antibody response to pneumococcal vaccination as a function of preimmunization titer
Creators: Nathaniel D Hare - Division of Allergy-Immunology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Brian J Smith - Department of Biostatistics, University of Iowa, Iowa City, Iowa
Zuhair K Ballas - Division of Allergy-Immunology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Journal of allergy and clinical immunology, Vol.123(1), pp.195-200
DOI: 10.1016/j.jaci.2008.09.021
PMID: 18951616
PMCID: PMC3613280
NLM abbreviation: J Allergy Clin Immunol
ISSN: 0091-6749
eISSN: 1097-6825
Publisher: Mosby, Inc
Language: English
Date published: 2009
Academic Unit: Biostatistics; Immunology; Holden Comprehensive Cancer Center; Internal Medicine
Record Identifier: 9984094485402771

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