Journal article
Antifibrinolytic therapy in the acute period following aneurysmal subarachnoid hemorrhage. Preliminary observations from the Cooperative Aneurysm Study
Journal of neurosurgery, Vol.61(2), pp.225-230
08/1984
DOI: 10.3171/jns.1984.61.2.0225
PMID: 6737046
Abstract
Antifibrinolytic therapy remains a controversial issue in the management of subarachnoid hemorrhage (SAH). The relationship of antifibrinolytic therapy with mortality, rebleeding, ischemia, hydrocephalus, and clotting abnormalities was studied in 672 patients in the International Cooperative Study on the Timing of Aneurysm Surgery. The patients with antifibrinolytic therapy had a significantly lower rebleeding rate, but higher rates of ischemic deficits and hydrocephalus. The net result was no difference in mortality in the 1st month following the initial SAH. Further clinical trials are needed to determine the overall effects of antifibrinolytic therapy.
Details
- Title: Subtitle
- Antifibrinolytic therapy in the acute period following aneurysmal subarachnoid hemorrhage. Preliminary observations from the Cooperative Aneurysm Study
- Creators
- Neal F KassellJames C TornerHarold P Adams Jr
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgery, Vol.61(2), pp.225-230
- DOI
- 10.3171/jns.1984.61.2.0225
- PMID
- 6737046
- NLM abbreviation
- J Neurosurg
- ISSN
- 0022-3085
- eISSN
- 1933-0693
- Publisher
- United States
- Grant note
- NS15940 / NINDS NIH HHS
- Language
- English
- Date published
- 08/1984
- Academic Unit
- Neurology; Epidemiology; Iowa Neuroscience Institute; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983996078502771
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