Journal article
Antifouling Photograftable Zwitterionic Coatings on PDMS Substrates
Langmuir, Vol.35(5), pp.1100-1110
02/05/2019
DOI: 10.1021/acs.langmuir.8b00838
PMCID: PMC6358520
PMID: 29983076
Abstract
The foreign body response (FBR) to implantable materials can negatively impact performance of medical devices such as the cochlear implant. Engineering surfaces that resist the FBR could lead to enhanced functionality including potentially improving outcomes for cochlear implant recipients through reduction in fibrosis. In this work, we coat poly(dimethylsiloxane) (PDMS) surfaces with two zwitterionic polymers, poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA), using a simultaneous photografting/photo-cross-linking process to produce a robust grafted zwitterionic hydrogel. reduce nonspecific protein adsorption, the first step of the FBR. The coating process uses benzophenone, a photografting agent and type II photoinitiator, to covalently link the cross-linked zwitterionic thin film to the PDMS surface. As the concentration of benzophenone on the surface increases, the adhesive strength of the zwitterionic thin films to PDMS surfaces increases as determined by shear adhesion. Additionally, with increased concentration of the adsorbed benzophenone, failure of the system changes from adhesive delamination to cohesive failure within the hydrogel, demonstrating that durable adhesive bonds are formed from the photografting process. Interestingly, antifouling properties of the zwitterionic polymers are preserved with significantly lower levels of nonspecific protein adsorption on zwitterion hydrogel-coated samples compared to uncoated controls. Fibroblast adhesion is also dramatically reduced on coated substrates. These results show that cross-linked pSBMA and pCBMA hydrogels can be readily photografted to PDMS substrates and show promise in potentially changing the fibrotic response to implanted biomaterials.
Details
- Title: Subtitle
- Antifouling Photograftable Zwitterionic Coatings on PDMS Substrates
- Creators
- Braden L LeighElise ChengLinjing XuAlexis DerkMarlan R HansenC Allan Guymon
- Resource Type
- Journal article
- Publication Details
- Langmuir, Vol.35(5), pp.1100-1110
- DOI
- 10.1021/acs.langmuir.8b00838
- PMID
- 29983076
- PMCID
- PMC6358520
- ISSN
- 0743-7463
- eISSN
- 1520-5827
- Grant note
- T32 DC000040 / NIDCD NIH HHS UL1 TR002537 / NCATS NIH HHS T35 HL007485 / NHLBI NIH HHS R01 DC012578 / NIDCD NIH HHS P30 DC010362 / NIDCD NIH HHS
- Language
- English
- Date published
- 02/05/2019
- Academic Unit
- Molecular Physiology and Biophysics; Chemical and Biochemical Engineering; Neurosurgery; Otolaryngology
- Record Identifier
- 9984197117602771
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