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Antifungal antibiotics and breakthrough bacteremias
Journal article   Open access   Peer reviewed

Antifungal antibiotics and breakthrough bacteremias

Richard P Wenzel, Chris Gennings and Michael B Edmond
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.32(11), pp.1538-1539
06/01/2001
DOI: 10.1086/320534
PMID: 11340523
url
https://doi.org/10.1086/320534View
Published (Version of record) Open Access

Abstract

Patients with fever and neutropenia are at high risk for infection ( approximately 50%) and bacteremia ( approximately 20%). As a result, most are treated with antibacterial prophylaxis until their absolute neutrophil count exceeds 500 cells/mm(3) and their temperature returns to normal. The 1997 guidelines of the Infectious Diseases Society of America suggested 1 of 3 regimens: vancomycin plus ceftazidime, monotherapy with ceftazidime or imipenem (possibly cefepime or meropenem), or dual therapy with an aminoglycoside plus an antipseudomonal beta-lactam.
Neutropenia - complications Mycoses - prevention & control Fever - complications Humans Bacteremia - epidemiology Antibiotic Prophylaxis - utilization Antifungal Agents - therapeutic use

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