Journal article
Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds
Current opinion in microbiology, Vol.57, pp.1-6
10/01/2020
DOI: 10.1016/j.mib.2020.03.005
PMCID: PMC7652037
PMID: 32339892
Abstract
Invasive fungal infections are responsible for a significant disease burden worldwide. Drugs to treat these infections are limited to only four unique classes, and despite these available treatments, mortality rates remain unacceptably high. In this review, we will discuss antifungal drug screening and how the approach to identifying novel compounds needs move away from traditional growth-based assays in order to meet the demand for new drugs. We highlight specific examples of creative screening strategies that increase the likelihood of identifying compounds with desired activities and provide perspective to inspire development of novel screens for the identification of first-in-class antifungals.
Details
- Title: Subtitle
- Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds
- Creators
- Sarah R. Beattie - Roy J. and Lucille A. Carver College of MedicineDamian J. Krysan - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Current opinion in microbiology, Vol.57, pp.1-6
- DOI
- 10.1016/j.mib.2020.03.005
- PMID
- 32339892
- PMCID
- PMC7652037
- NLM abbreviation
- Curr Opin Microbiol
- ISSN
- 1369-5274
- eISSN
- 1879-0364
- Publisher
- Current Biology Ltd
- Number of pages
- 6
- Grant note
- 1F32AI145160-01A1; 1R01AI120958 / N.I.H.; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 10/01/2020
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984297329102771
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