Antifungal drugs and the risk of selected birth defects

Tonia C Carter; Charlotte M Druschel; Paul A Romitti; Erin M Bell; Martha M Werler; Allen A Mitchell; National Birth Defects Prevention Study

doi:10.1016/j.ajog.2007.08.044

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Antifungal drugs and the risk of selected birth defects

Journal article

Peer reviewed

Antifungal drugs and the risk of selected birth defects

Tonia C Carter, Charlotte M Druschel, Paul A Romitti, Erin M Bell, Martha M Werler, Allen A Mitchell and National Birth Defects Prevention Study

American journal of obstetrics and gynecology, Vol.198(2), pp.191.e1-191.e7

2008

DOI: 10.1016/j.ajog.2007.08.044

PMID: 18226621

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Abstract

This study examined whether first-trimester antifungal drug use was associated with the risk of selected birth defects. Subjects were participants in a case-control study, the National Birth Defects Prevention Study, with singleton deliveries from 1997 to 2003. Based on maternal interviews, first-trimester antifungal drug use was compared between 7047 cases with isolated defects and 4774 nonmalformed controls using unconditional logistic regression. Risk was elevated for hypoplastic left heart syndrome (odds ratio, 2.30; 95% confidence interval, 1.04, 5.06) but not for other cardiovascular defects. An increased risk of 1.88 was observed for diaphragmatic hernia but was not statistically significant. Estimates approximated unity for neural tube defects, oral clefts, anorectal atresia, hypospadias, and craniosynostosis. First-trimester antifungal drug exposure was not strongly associated with the risk of most birth defects, but further studies should examine the preliminary results of an association with hypoplastic left heart syndrome.

antifungal agents

congenital abnormalities

teratogens

pregnancy

Details

Title: Subtitle: Antifungal drugs and the risk of selected birth defects
Creators: Tonia C Carter - Department of Epidemiology, School of Public Health, State University of New York at Albany, Albany
Charlotte M Druschel - Department of Epidemiology, School of Public Health, State University of New York at Albany, Albany
Paul A Romitti - Department of Epidemiology, University of Iowa College of Medicine, Iowa City, IA
Erin M Bell - Department of Epidemiology, School of Public Health, State University of New York at Albany, Albany
Martha M Werler - Slone Epidemiology Center at Boston University, Boston, MA
Allen A Mitchell - Slone Epidemiology Center at Boston University, Boston, MA
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.198(2), pp.191.e1-191.e7
DOI: 10.1016/j.ajog.2007.08.044
PMID: 18226621
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Mosby, Inc
Language: English
Date published: 2008
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995163102771

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