Journal article
Antifungal metabolites (monorden, monocillins I, II, III) from Colletotrichum graminicola, a systemic vascular pathogen of maize
Mycological research, Vol.113(12), pp.1433-1442
2009
DOI: 10.1016/j.mycres.2009.10.001
PMID: 19825415
Abstract
Colletotrichum graminicola is a systemic vascular pathogen that causes anthracnose stalk rot and leaf blight of maize. In the course of an effort to explore the potential presence and roles of
C. graminicola metabolites in maize, ethyl acetate extracts of solid substrate fermentations of several
C. graminicola isolates from Michigan and Illinois were found to be active against
Aspergillus flavus and
Fusarium verticillioides, both mycotoxin-producing seed-infecting fungal pathogens. Chemical investigations of the extract of one such isolate (NRRL 47511) led to the isolation of known metabolites monorden (also known as radicicol) and monocillins I–III as major components. Monorden and monocillin I displayed
in vitro activity against the stalk- and ear-rot pathogen
Stenocarpella maydis while only the most abundant metabolite (monorden) showed activity against foliar pathogens
Alternaria alternata,
Bipolaris zeicola, and
Curvularia lunata. Using LC–HRESITOFMS, monorden was detected in steam-sterilized maize stalks and stalk residues inoculated with
C. graminicola but not in the necrotic stalk tissues of wound-inoculated plants grown in an environmental chamber. Monorden and monocillin I can bind and inhibit plant Hsp90, a chaperone of R-proteins. It is hypothesized that monorden and monocillins could support the
C. graminicola disease cycle by disrupting maize plant defenses and by excluding other fungi from necrotic tissues and crop residues. This is the first report of natural products from
C. graminicola, as well as the production of monorden and monocillins by a pathogen of cereals.
Details
- Title: Subtitle
- Antifungal metabolites (monorden, monocillins I, II, III) from Colletotrichum graminicola, a systemic vascular pathogen of maize
- Creators
- Donald T Wicklow - Mycotoxin Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDA, Peoria, IL 61604, USAAnnalisa M Jordan - Department of Chemistry, University of Iowa, Iowa City, IA 52242, USAJames B Gloer - Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Mycological research, Vol.113(12), pp.1433-1442
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.mycres.2009.10.001
- PMID
- 19825415
- ISSN
- 0953-7562
- eISSN
- 1469-8102
- Language
- English
- Date published
- 2009
- Academic Unit
- Chemistry
- Record Identifier
- 9984216681302771
Metrics
20 Record Views