Journal article
Antigen Recognition Determinants of γδ T Cell Receptors
Science (American Association for the Advancement of Science), Vol.308(5719), pp.252-255
04/08/2005
DOI: 10.1126/science.1106480
PMID: 15821090
Abstract
The molecular basis of γδ T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural γδ T cell population specific for the major histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates strongly with a somatically recombined TCRδ complementarity-determining region 3 (CDR3) motif derived from germ line–encoded residues. Sequence diversity around these residues modulates TCR ligand-binding affinities, whereas V gene usage correlates mainly with tissue origin. These results show how an antigen-specific γδ TCR repertoire can be generated at a high frequency and suggest that γδ T cells recognize a limited number of antigens.
Details
- Title: Subtitle
- Antigen Recognition Determinants of γδ T Cell Receptors
- Creators
- Sunny Shin - Stanford UniversityRamy El-Diwany - Stanford University School of MedicineSteven Schaffert - Institut PasteurErin J. Adams - Institut PasteurK. Christopher Garcia - Institut PasteurPablo Pereira - Stanford UniversityYueh-hsiu Chien - Stanford University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.308(5719), pp.252-255
- DOI
- 10.1126/science.1106480
- PMID
- 15821090
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE; WASHINGTON
- Number of pages
- 4
- Language
- English
- Date published
- 04/08/2005
- Academic Unit
- Surgery
- Record Identifier
- 9984966855202771
Metrics
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